Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells
1991; American Society for Microbiology; Volume: 59; Issue: 10 Linguagem: Inglês
10.1128/iai.59.10.3827-3831.1991
ISSN1098-5522
AutoresAmbrose L. Cheung, Michael Koomey, S Lee, E A Jaffe, Vincent A. Fischetti,
Tópico(s)Immune Response and Inflammation
ResumoTumor necrosis factor (TNF), a potent inflammatory mediator secreted by monocytes during inflammation, was shown to significantly increase the adherence of Staphylococcus aureus to cultured human umbilical vein endothelial cells in vitro. The stimulatory effect of TNF was dose dependent and was bimodal with respect to time; bacterial adhesion peaked after 4 and 16 h of stimulation with recombinant human TNF-alpha. The ability of TNF-alpha to augment staphylococcal adherence to endothelial cells was contingent upon the presence of plasma factors. Thus, the complex interaction among cytokines (such as TNF), plasma factor(s), and the endothelium serves to modulate bacterial adherence to endothelial cells.
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