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Factors affecting fecundity among sperm donors: a multivariate analysis

2011; Wiley; Volume: 43; Issue: 3 Linguagem: Inglês

10.1111/j.1439-0272.2009.01036.x

1439-0272

Jie Hu, Wenbing Zhu, W. Liu, Liqing Fan,

Assisted Reproductive Technology and Twin Pregnancy

AndrologiaVolume 43, Issue 3 p. 155-162 ORIGINAL ARTICLE Factors affecting fecundity among sperm donors: a multivariate analysis J. Hu, J. Hu Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China;Search for more papers by this authorW. Zhu, W. Zhu Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China;Search for more papers by this authorW. Liu, W. Liu Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, ChinaSearch for more papers by this authorL. Fan, L. Fan Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China; Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, ChinaSearch for more papers by this author J. Hu, J. Hu Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China;Search for more papers by this authorW. Zhu, W. Zhu Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China;Search for more papers by this authorW. Liu, W. Liu Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, ChinaSearch for more papers by this authorL. Fan, L. Fan Human Sperm Bank, Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, China; Central South University, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, ChinaSearch for more papers by this author First published: 25 February 2011 https://doi.org/10.1111/j.1439-0272.2009.01036.xCitations: 8 Prof. Liqing Fan, Reproductive and Genetic Hospital of Citic Xiangya, Changsha, Hunan 410078, China.Tel./Fax: +00 86 0731 84805322;E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary The study was aimed at identifying the predictors of the male fertility potential among sperm donors. Fifty anonymous donors undergoing 683 intracervical insemination (ICI) cycles between January 2002 and December 2006 were retrospectively evaluated according to semen characteristics in terms of reproduction rate (RR). We used RR as a parameter to determine the fertility potential among sperm donors. The overall RR was 26.79%. There were no significant differences among low, mean and high RR groups with regard to most sperm routine parameters. However, the RR was notably higher in the sperm morphology of ≥18% than in the <18% group (26.2% versus 19.4% respectively; P < 0.01). Both post-thaw total motility and progressive motility were proportional to RR (P < 0.01). Differences in RR were seen when the percentage of propidium iodide-negative spermatozoa was ≥45% (26.2% versus 16.4% respectively; P < 0.01) and DNA fragmentation index (DFI) was <8% (37.5% versus 17.9% respectively; P < 0.01) in post-thaw samples. Using stepwise linear regression analysis, the percentage of normal morphology, post-thaw progressive motility, PI-negative spermatozoa, DFI had the maximum power to predict the donor fecundity in ICIs. Conclusion: Both the integrity of plasma membrane and DNA in spermatozoa are crucial factors affecting the fecundity of sperm donors. Therefore, the addition of some of these new tests to routine semen analysis could significantly improve the recruitment of sperm donors and the clinical pregnancy rate of anonymous donors. References Aitken RJ, Baker MA (2006) Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol 250: 66–69. 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