Produção Nacional
Revisado por pares
Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
2009; Springer Science+Business Media; Volume: 19; Issue: 4 Linguagem: Inglês
10.1590/s0102-695x2009000600009
ISSN1981-528X
AutoresIracilda Zeppone Carlos, Camila B. A. Carli, Danielle Cardoso Geraldo Maia, Fernanda Paulin Benzatti, Flávia Cristine Mascia Lopes, Fernanda Mesquita Roese, Márcio Watanabe, Ana Camila Micheletti, Lourdes Campaner dos Santos, Wagner Vilegas, Neli Kika Honda,
Tópico(s)Allergic Rhinitis and Sensitization
ResumoThe effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
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