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High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study

2011; Wiley; Volume: 58; Issue: 7 Linguagem: Inglês

10.1111/j.1365-2559.2011.03863.x

1365-2559

Alan Roger Santos‐Silva, Ana Carolina Prado Ribeiro, Ana Maria Pires Soubhia, Glauco Issamu Miyahara, Román Carlos, Paul M. Speight, Keith D. Hunter, A. Torres‐Rendon, Pablo Agustín Vargas, Márcio Ajudarte Lopes,

Cholangiocarcinoma and Gallbladder Cancer Studies

HistopathologyVolume 58, Issue 7 p. 1127-1135 High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study Alan Roger Santos-Silva, Alan Roger Santos-Silva Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorAna Carolina Prado Ribeiro, Ana Carolina Prado Ribeiro Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorAna Maria Pires Soubhia, Ana Maria Pires Soubhia Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, BrazilSearch for more papers by this authorGlauco Issamu Miyahara, Glauco Issamu Miyahara Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, BrazilSearch for more papers by this authorRoman Carlos, Roman Carlos Centro Clinico de Cabeza y Cuello, Guatemala City, GuatemalaSearch for more papers by this authorPaul M. Speight, Paul M. Speight Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorKeith D. Hunter, Keith D. Hunter Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorAlica Torres-Rendon, Alica Torres-Rendon Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorPablo Agustin Vargas, Pablo Agustin Vargas Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorMarcio Ajudarte Lopes, Marcio Ajudarte Lopes Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this author Alan Roger Santos-Silva, Alan Roger Santos-Silva Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorAna Carolina Prado Ribeiro, Ana Carolina Prado Ribeiro Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorAna Maria Pires Soubhia, Ana Maria Pires Soubhia Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, BrazilSearch for more papers by this authorGlauco Issamu Miyahara, Glauco Issamu Miyahara Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, BrazilSearch for more papers by this authorRoman Carlos, Roman Carlos Centro Clinico de Cabeza y Cuello, Guatemala City, GuatemalaSearch for more papers by this authorPaul M. Speight, Paul M. Speight Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorKeith D. Hunter, Keith D. Hunter Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorAlica Torres-Rendon, Alica Torres-Rendon Department of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UKSearch for more papers by this authorPablo Agustin Vargas, Pablo Agustin Vargas Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this authorMarcio Ajudarte Lopes, Marcio Ajudarte Lopes Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, BrazilSearch for more papers by this author First published: 27 June 2011 https://doi.org/10.1111/j.1365-2559.2011.03863.xCitations: 32 Marcio Ajudarte Lopes, DDS, PhD, Oral Diagnosis Department (Oral Pathology and Semiology Areas), Piracicaba Dental School, Campinas State University (UNICAMP), Avenida Limeira 901, Caixa Postal 52, Piracicaba – SP, CEP: 13414-903, Brasil. e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Santos-Silva A R, Ribeiro A C P, Soubhia A M P, Miyahara G I, Carlos R, Speight P M, Hunter K D, Torres-Rendon A, Vargas P A & Lopes M A (2011) Histopathology 58, 1127–1135High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study Aims: This multi-centre analysis assessed the DNA content of TSCC in 37 young patients ( 50 years) and determined the correlation of DNA ploidy findings with clinicopathological data. Methods and results: Image cytometry was carried out using an automated cellular imaging system on Feulgen-stained histological sections to obtain high-fidelity DNA histograms. Among young patients, 37.8% were females compared to 18.7% in the older group (P = 0.002). In total, 48.6% patients were non-smokers and 40.5% were non-drinkers compared to 10.7% non-smokers and non-drinkers in the older group (P < 0.0001). TNM, clinical stage of disease and histological grade of differentiation did not differ between groups. Tumour aneuploidy was detected in 86.5% and tetraploidy in 24.3% young patients; this was significantly greater than in the older group where 64.3% were aneuploid (P < 0.0001) and 7.2% tetraploid (P < 0.0001). The mean values of DNA index (DI) and DNA heterogeneity index as well as the percentage of cells with DI exceeding 5N were higher in young patients (P < 0.0001). Conclusions: Young patients with TSCC represent a distinct clinical entity. The high incidence of DNA ploidy abnormalities suggest that they may have increased genomic instability and indicates underlying genetic differences between TSCC in young and older patients. Citing Literature Volume58, Issue7June 2011Pages 1127-1135 RelatedInformation