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BIBTEX RIS

Phenotypic and genotypic profile of pyrethroid resistance in populations of the mosquito Aedes aegypti from Goiânia, Central West Brazil

2015; Brazilian Society of Tropical Medicine; Volume: 48; Issue: 5 Linguagem: Inglês

10.1590/0037-8682-0046-2015

ISSN

1678-9849

Autores

Francesca Guaracyaba Garcia Chapadense, Éverton K. K. Fernandes, José Bento Pereira Lima, Ademir Jesus Martins, Luana Carrara Da Silva, Welington Tristão da Rocha, Adelair Helena dos Santos, Pedro Cravo,

Tópico(s)

Malaria Research and Control

Resumo

INTRODUCTION: The mosquito Aedes aegypti has evolved resistance to pyrethroid insecticides. The present study evaluated Ae. aegypti from Goiânia for the resistant phenotype and for mutations associated with resistance. METHODS: Insecticide dose-response bioassays were conducted on mosquitoes descended from field-collected eggs, and polymerase chain reaction (PCR) was used to genotype 90 individuals at sites implicated in pyrethroid resistance. RESULTS: All mosquito populations displayed high levels of resistance to deltamethrin, as well as high frequencies of the 1016Ile kdr and 1534Cys kdrmutations. CONCLUSIONS: Aedes aegypti populations in the Goiânia area are highly resistant to deltamethrin, presumably due to high frequencies of kdr(knockdown-resistance) mutations.

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