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Lymphocyte Subsets in Habitual Abortion

1986; Wiley; Volume: 12; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0897.1986.tb00051.x

2374-8192

I Virág, E. SCHECTER, Maya Elgat, H Zakut, Dina Meytes,

Reproductive System and Pregnancy

Lymphocyte subpopulations were characterized by means of monoclonal antibodies in 25 women with habitual abortion and 21 multiparous normal women. Compared to nonpregnant women (N = 8), pregnant normal women were associated with significantly lower helper-to-suppressor ratios (1.71 +/- 0.41 versus 2.37 +/- 0.66). In contrast in pregnant women with habitual abortion (N = 13) the ratio remained high (2.32 +/- 0.73). Failure to increase the number of suppressors and a significant rise in helpers caused this increased ratio. We discuss the possible mechanisms and etiological importance of this finding in habitual abortion.