Portal de Periódicos da CAPES

Practical olefin hydroamination with nitroarenes

2015; American Association for the Advancement of Science; Volume: 348; Issue: 6237 Linguagem: Inglês

10.1126/science.aab0245

1095-9203

Jinghan Gui, Chung-Mao Pan, Ying Jin, Tian Qin, Julian C. Lo, Bryan J. Lee, Steven H. Spergel, Michael Mertzman, William J. Pitts, Thomas E. La Cruz, Michael A. Schmidt, Nitin B. Darvatkar, S. Natarajan, Phil S. Baran,

Asymmetric Hydrogenation and Catalysis

Stitching C-N bonds from nitro groups Numerous compounds in pharmaceutical research have carbon-nitrogen bonds, and chemists are always looking for ways to make them more efficiently. Gui et al. present a method that links the carbon in an olefin to the nitrogen in a nitroaromatic compound (see the Perspective by Kürti). Nitroaromatics are readily available, and the method tolerates a wide range of other chemical groups present on either reacting partner. Science , this issue p. 886 ; see also p. 863