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Study of the safety of methylphenidate: Focus on nephrotoxicity aspects

2015; Elsevier BV; Volume: 141; Linguagem: Inglês

10.1016/j.lfs.2015.09.014

1879-0631

Luiza Herbene Macedo Soares Salviano, Maria Isabel Linhares, Klistenes Alves de Lima, Alana Gomes de Souza, Dânya Bandeira Lima, Antônio Rafael Coelho Jorge, Marcus Felipe Bezerra da Costa, Adriano José Maia Chaves Filho, Alice Maria Costa Martins, Helena Serra Azul Monteiro, Teresa Maria de Jesus Ponte Carvalho, Marta Maria de França Fonteles,

Electroconvulsive Therapy Studies

Methylphenidate (MPD) is increasingly prescribed for the treatment of Attention Deficit Hyperactivity Disorder and there are concerns about its appropriate use. Furthermore, little is known about the potential nephrotoxicity in patients using MPD. This study aimed to investigate the safety of MPD, with focus on the possible effects of this drug on renal function. We investigated the effects of MPD on renal perfusion system and renal tubular cells through in vivo and in vitro experimental models. In the in vivo experiments, 24 h and 48 h after MPD administration, urea, creatinine, creatinine clearance, and the fractional excretion of sodium and potassium were not changed. In the isolated kidney perfusion, MPD significantly reduced urinary flow, glomerular filtration rate and the percentage of tubular sodium transport. However, the perfusion pressure, renal vascular resistance and the percentage of tubular potassium transport were unchanged in this system. In the canine renal epithelial cell line MDCK culture, MPD was not cytotoxic and, in histopathological analysis, MPD did not promote alterations. Our findings suggest a possible nephrotoxic effect of MPD, since it altered renal function by reducing the glomerular activity, urinary flow and sodium transport. These effects need to be further investigated in order to minimize potential harms associated with the use of MPD.