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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Biological characterization of human monoclonal antibodies to rabies virus

1990; American Society for Microbiology; Volume: 64; Issue: 6 Linguagem: Inglês

10.1128/jvi.64.6.3087-3090.1990

ISSN

1098-5514

Autores

Bernhard Dietzschold, Milind M. Gore, Paolo Casali, Y Ueki, Charles E. Rupprecht, A L Notkins, Hilary Koprowski,

Tópico(s)

Virology and Viral Diseases

Resumo

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

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