Portal de Periódicos da CAPES

Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

2015; Elsevier BV; Volume: 126; Issue: 19 Linguagem: Inglês

10.1182/blood-2015-04-639203

1528-0020

Clare Sun, Xin Tian, Yuh Shan Lee, Sreenivasulu Gunti, Andrew Lipsky, Sarah E. M. Herman, Dalia Salem, Maryalice Stetler‐Stevenson, Constance M. Yuan, Lela Kardava, Susan Moir, Irina Marić, Janet Valdez, Susan Soto, Gerald E. Marti, Mohammed Farooqui, Abner Louis Notkins, Adrian Wiestner, Georg Aue,

Lymphoma Diagnosis and Treatment

Key Points Ibrutinib allows for partial reconstitution of normal B cells and humoral immunity in patients with chronic lymphocytic leukemia. Infection rate decreased with time on ibrutinib and was inversely correlated with improvements in serum IgA.