Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa
1992; Elsevier BV; Volume: 102; Issue: 6 Linguagem: Inglês
10.1016/0016-5085(92)90348-3
ISSN1528-0012
AutoresMauricio Lisker‐Melman, Adrian M. Di Bisceglie, Stephen J. Usala, Bruce D. Weintraub, Linda Murray, Jay H. Hoofnagle,
Tópico(s)Hepatitis C virus research
ResumoSix of 237 (2.5%) patients with chronic viral hepatitis who were treated with recombinant interferon alfa developed thyroid disease while on treatment. Three patients developed hyperthyroidism, two of whom developed detectable levels of thyroid-stimulating immunoglobulin; three patients developed hypothyroidism in association with high titers of antithyroglobulin and/or antimicrosomal antibodies. The thyroid disease did not remit when interferon therapy was stopped, and all six patients required definitive therapy for the thyroid disease. These findings suggest that a small proportion of patients treated with interferon alfa develop autoimmune reactions and can develop autoimmune thyroid disease.
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