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The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model

2011; Wiley; Volume: 37; Issue: 8 Linguagem: Inglês

10.1111/j.1447-0756.2010.01482.x

1341-8076

Tuncer Çaycı, Emin Özgür Akgül, Yasemin Gülcan Kurt, Temel Ceyhan, İbrahim Aydın, Önder Öngürü, Halıl Yaman, Erdinç Çakır, Mehmet Yaşar, Cumhur Bilgi, Kemal Erbil,

Reproductive System and Pregnancy

Abstract Aim: To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models. Material & Methods: Forty‐one rats with endometriotic implants were divided into four groups (1 to 4) and administered infliximab, etanercept, letrozole and control, respectively. There were 11 rats in group 5 (normal). The size of implants, plasma ADMA and nitrate/nitrite (NO x ) levels and histological score were assessed. Results: In groups 1, 2 and 3, plasma ADMA levels were higher than groups 4 and 5, 296.8 ± 66.2, 285.9 ± 35.7, 200.3 ± 41.0, 125.3 ± 16.7, 111.3 ± 6.5 µmol/L, respectively, while NO x levels were lower than groups of control and normal 19.6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively. Conclusions: Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO x levels, and increased plasma ADMA levels.