A new device for rapid isolation by size and characterization of rare circulating tumor cells.
2011; National Institutes of Health; Volume: 31; Issue: 2 Linguagem: Inglês
Autores
Isabelle Desitter, Bella S. Guerrouahen, Naoual Benali-Furet, Janine Wechsler, Pasi A. Jänne, Yanan Kuang, Masahiko Yanagita, Xin Lin, Jillian A Berkowitz, R Distel, Yvon E. Cayre,
Tópico(s)Microfluidic and Bio-sensing Technologies
ResumoCirculating tumor cells (CTCs) likely derive from clones in the primary tumor, suggesting that they can be used for all biological tests applying to the primary cells.The ScreenCell® devices are single-use and low-cost innovative devices that use a filter to isolate and sort tumor cells by size.The ScreenCell® Cyto device is able to isolate rare, fixed, tumor cells, with a high recovery rate. Cells are well preserved morphologically. Immunocytochemistry and FISH assays can be performed directly on the filter. The ScreenCell® CC device allows isolation of live cells able to grow in culture. High quality genetic materials can be obtained directly from tumor cells isolated on the ScreenCell® MB device filter.Due to their reduced size, versatility, and capacity to isolate CTCs within minutes, the ScreenCell® devices may be able to simplify and improve non-invasive access to tumor cells.
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