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Urinary Excretion of Amitriptyline N-Oxide in Humans

1974; Elsevier BV; Volume: 63; Issue: 11 Linguagem: Inglês

10.1002/jps.2600631104

1520-6017

Giuseppe Santagostino, Roberto Maffei Facino, D. Pirillo,

Pharmacological Effects and Toxicity Studies

Abstract: The excretion rate of amitriptyline N - oxide was measured in healthy human subjects after the administration of a single oral dose of amitriptyline. The total amount of this metabolite excreted accounted for about 1% of the dose. It appears in the urine soon after administration of the parent compound but has practically disappeared by the 9th hr after treatment. The role of this metabolite in amitriptyline degradation in humans is discussed.