Human Serum Concentrations of all-trans β- and α-Carotene but Not 9-cis β-Carotene Increase upon Ingestion of a Natural Isomer Mixture Obtained from Dunaliella salina (Betatene)
1993; Elsevier BV; Volume: 123; Issue: 5 Linguagem: Inglês
10.1093/jn/123.5.847
ISSN1541-6100
AutoresWilhelm Stahl, Wolfgang Schwarz, Helmut Sies,
Tópico(s)Vitamin C and Antioxidants Research
ResumoThe uptake of all-trans and 9-cis β-carotene and of α-carotene from a natural carotene preparation from Dunaliella salina, Betatene, was studied in humans. All-trans β-carotene and α-carotene were absorbed well and showed the expected biokinetics with serum peak concentrations between 24 and 48 h. The mean increase in serum concentrations of α-carotene was 5.6% of the increase of all-trans β-carotene, reflecting the composition of these carotenoids in Betatene. 9-cis β-Carotene, however, was not detected in human serum, even after repeated doses. This could be due to preferential absorption of all-trans β-carotene, rapid distribution of 9-cis β-carotene into the tissue, or the presence of isomerase activity processing 9-cis to all-trans β-carotene.
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