Editorial Revisado por pares

Stroke and Potentially Preventable Dementias Proclamation

2015; Lippincott Williams & Wilkins; Volume: 46; Issue: 11 Linguagem: Inglês

10.1161/strokeaha.115.011237

ISSN

1524-4628

Autores

Vladimir Hachinski,

Tópico(s)

Neurological Disease Mechanisms and Treatments

Resumo

HomeStrokeVol. 46, No. 11Stroke and Potentially Preventable Dementias Proclamation Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBStroke and Potentially Preventable Dementias ProclamationUpdated World Stroke Day Proclamation Vladimir Hachinski, MD, DScon behalf of the World Stroke Organization Vladimir HachinskiVladimir Hachinski From the Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Rd, London, Ontario, Canada N6A 5A5. E-mail and on behalf of the World Stroke Organization Originally published1 Nov 2015https://doi.org/10.1161/STROKEAHA.115.011237Stroke. 2015;46:3039–3040is corrected byCorrectionCorrectionThe growing epidemicStroke1 and some dementias may be preventable2 but are rising globally.Aging, unhealthy diets, tobacco use, and physical inactivity fuel a growing epidemic of high blood pressure, high cholesterol, obesity, diabetes mellitus, stroke, heart disease, and dementia.3Worldwide, stroke and potentially preventable dementias are the leading causes of serious disability, sparing no age, sex, ethnic origin, or country.4The incidence of stroke is falling by half in high-income countries but increasing in low- and middle-income countries5 that can least afford to deal with the consequences.Millions of deaths and much disability could be averted over the next decade if what is already known is applied.Join forces to prevent stroke and potentially preventable dementiasThe same few risk factors account for the leading health problems of the world, but research about the common threat occurs in isolation from other major chronic diseases.The common risk factors, tobacco use, alcohol misuse, physical inactivity, and diets high in salt, fats, and sugar, contribute to stroke, heart disease, diabetes mellitus, chronic lung disease, and cancer6 and pose a risk of dementia. Therefore, we need to:Support and catalyze the United Nations and the World Health Organization campaigns against noncommunicable diseases.Prevent obesity7 and promote diets that delay age-related diseases.8Ensure what we know becomes what is donePrevention is the most readily applicable and affordable part of our knowledge, but prevention is neglected. Therefore, we need to:Encourage healthy environments to support healthy habits and lifestyles.Provide drugs for primary and secondary prevention for cerebrovascular disease, an important risk factor for dementia. Regretfully, these drugs are neither accessible nor affordable in many developing countries or used optimally in developed ones.Discourage unproven, costly, or misdirected practices that drain resources from more cost-effective approaches.Educate health professionals at all levels through a common vocabulary, a core curriculum, on-line materials, long-distance mentoring, and opportunities for learning in clinical practice settings.Recognize the uniqueness of strokeThe different types of stroke, ischemic (blockage of arteries), bleeding into (intracerebral hemorrhage) and around the brain (subarachnoid hemorrhage) have specific courses requiring special treatment and rehabilitation. Therefore, we need to:Study their causes and understand their mechanisms.Organize skilled teams of physicians, neurosurgeons, neurointerventionalists, and rehabilitation specialists to manage these types of stroke.Incorporate the prevention of poststroke dementia as an integral part of stroke care.Prevent, identify, and treat potentially preventable dementiasSubclinical (silent) strokes occur 5 times as often as clinical (obvious) strokes9 and may affect thinking, mood, and personality.All major dementias have a vascular component, including 80% in Alzheimer disease.10 Therefore, we need to:Identify and treat the vascular component of all cognitive impairments.Understand that the presence of a vascular component doubles the chances that silent neurodegenerative pathology will lead to dementia.10Manage the common risk factors for stroke, vascular cognitive impairment, dementia (tobacco use, high blood pressure, high cholesterol, physical inactivity, obesity, and diabetes mellitus), and atrial fibrillation. Encourage frequent blood pressure measurements and checking for an irregular heartbeat to detect atrial fibrillation.Enhance protective factors, such as education and a socially and physically healthy environment.Integrate stroke and dementia prevention strategies because preventing stroke may prevent some dementias.11Build transdisciplinary teams for stroke and dementia care and rehabilitationOrganized stroke and dementia care improves outcomes but remains the exception nearly everywhere. Therefore, we need to:Establish simple but comprehensive stroke units that include rehabilitation and stroke prevention clinics. Build expertise in rehabilitation and management of complications, including poststroke epilepsy. Stroke units have long proven their worth, even in their most basic form.12Encourage transdisciplinary teams to develop expertise and translate evidence into practice.Build a healthcare system that responds to the needs of each individual challenged by the effect of stroke and/or dementia and facilitate their optimal functioning in society.Support and inform people living with stroke, their caregivers, and familiesStroke often results in long-term disability affecting all aspects of daily living. Yet people affected by stroke are often not supported or informed about their stroke or their options to maximize their recovery. Therefore, we need to:Support people affected by stroke and their caregivers in their recovery, in their return to work, and in life after stroke.Work to ensure that people affected by stroke are included in all aspects of society.Encourage systems to connect stroke survivors to each other and caregivers.Actively engage the public around the worldThe public, acting as individuals, voters, or advocates, can best influence their own future risk and care but not enough is being done. Therefore, we need to:Increase the knowledge of the public, policymakers, and health professionals about causes and symptoms of stroke and dementia. The symptoms of stroke are painless and at times, transient; however, sudden weakness or numbness in the face, arm or leg, sudden inability to speak or understand speech, loss of vision in one eye, or sudden loss of balance are as compelling an emergency as crushing chest pain or sudden, severe unusual headache.Send a unified, consistent message throughout the world: stroke and some dementias may be preventable.Whereas; stroke and potentially preventable dementias are global epidemics that threaten lives, health, and quality of life.Whereas; much can be done to prevent and treat stroke and potentially preventable dementias and rehabilitate those who suffer from these.Whereas; professional and public awareness is the first step to action.We hereby proclaim an annualWORLD STROKE DAYUpdating CommitteeVladmir Hachinski (Chair), Natan Bornstein, Michael Brainin, Stephen Davis, Geoffrey Donnan, Gloria Ekeng, Marc Fisher, Werner Hacke, Sheila Martins, Erin Lalor, Ming Liu, Bo Norrving, Jeyaraj Pandian, Lawrence Wong, Shinichiro Uchiyama, and Bernard Yan.List of supporting organizations for the updateAlzheimer's Disease International, World Federation of Neurosurgical Societies, World Federation of NeuroRehabilitation, American Academy of Neurology, International Brain Research Organization, World Federation of Neurology, American Heart Association/American Stroke Association, World Psychiatric Association, World Heart Federation, The Heart and Stroke Foundation of Canada, Alzheimer's Association, European Academy of Neurology, Alzheimer Society of Canada, Public Health England, Alzheimer's Society (UK), Stroke Association (UK), European Stroke Organisation (ESO), European Brain Council, International Society of Vascular Behavioural and Cognitive Disorders, the Asian Society Against Dementia, Hypertension Canada and World Hypertension League.DisclosuresNone.FootnotesSee related article, page 3137.This article has been copublished in the International Journal of Stroke.References1. Hachinski V.World Stroke Day Proclamation.Stroke. 2008; 39:2409–2420.LinkGoogle Scholar2. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, et al. Stroke: working toward a prioritized world agenda.Stroke. 2010; 41:1084–1099. doi: 10.1161/STROKEAHA.110.586156.LinkGoogle Scholar3. Mendis S.Global status report on noncommunicable diseases 2014: World Health Organization. http://www.who.int/global-coordination-mechanism/publications/global-status-report-ncds-2014-eng.pdf. Accessed August 5, 2015.Google Scholar4. Neurological disorders. Public Health Challenges. Switzerland. WHO Press2007; 2:33. http://www.who.int/mental_health/neurology/neurodiso/en/. Accessed August 5, 2015Google Scholar5. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V.Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review.Lancet Neurol. 2009; 8:355–369. doi: 10.1016/S1474-4422(09)70025-0.CrossrefMedlineGoogle Scholar6. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study. 2013.The Lancet. 2015; 385: 117–171.CrossrefMedlineGoogle Scholar7. Nguyen JC, Killcross AS, Jenkins TA.Obesity and cognitive decline: role of inflammation and vascular changes.Front Neurosci. 2014; 8:375. doi: 10.3389/fnins.2014.00375.CrossrefMedlineGoogle Scholar8. Everitt AV, Hilmer SN, Brand-Miller JC, Jamieson HA, Truswell AS, Sharma AP, et al. Dietary approaches that delay age-related diseases.Clin Interv Aging. 2006; 1:11–31.CrossrefMedlineGoogle Scholar9. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM.Silent brain infarcts and the risk of dementia and cognitive decline.N Engl J Med. 2003; 348:1215–1222. doi: 10.1056/NEJMoa022066.CrossrefMedlineGoogle Scholar10. Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre.Brain. 2013; 136(Pt 9):2697–2706. doi: 10.1093/brain/awt188.CrossrefMedlineGoogle Scholar11. Sposato LA, Kapral MK, Wu J, Gill SS, Hackam DG, Cipriano LE, Hachinski V.Declining incidence of stroke and dementia: coincidence or prevention opportunity?JAMA Nerurology. 2015. In press.Google Scholar12. Stroke Unit Trialists' Collaboration. Organised inpatient (stroke unit) care for stroke.Cochrane Database Syst Rev. 2013; 9:CD00197.Google Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Hachinski V and Avan A (2022) From Dementia to Eumentia: A New Approach to Dementia Prevention, Neuroepidemiology, 10.1159/000525219, (1-6) Liu X, Ouyang F, Hu L, Sun P, Yang J, Sun Y, Liao M, Lan L, Pei Z and Fan Y (2022) Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease, Frontiers in Aging Neuroscience, 10.3389/fnagi.2022.883503, 14 Sun W, Huang L, Cheng Y, Qin R, Xu H, Shao P, Ma J, Yao Z, Shi L and Xu Y (2022) Medial Temporal Atrophy Contributes to Cognitive Impairment in Cerebral Small Vessel Disease, Frontiers in Neurology, 10.3389/fneur.2022.858171, 13 Huang Y, Chen S, Leng X, Kuo K, Wang Z, Cui M, Tan L, Wang K, Dong Q, Yu J and Galimberti D Post-Stroke Cognitive Impairment: Epidemiology, Risk Factors, and Management, Journal of Alzheimer's Disease, 10.3233/JAD-215644, 86:3, (983-999) Morovatdar N, Avan A, Azarpazhooh M, Di Napoli M, Stranges S, Kapral M, Rezayat A, Shariatzadeh A, Abootalebi S, Mokhber N, Spence J and Hachinski V (2021) Secular trends of ischaemic heart disease, stroke, and dementia in high-income countries from 1990 to 2017: the Global Burden of Disease Study 2017, Neurological Sciences, 10.1007/s10072-021-05259-2, 43:1, (255-264), Online publication date: 1-Jan-2022. Dobrynina L, Alexandrova E, Zabitova M, Kalashnikova L, Krotenkova M and Akhmetzyanov B (2021) Anti-NR2 glutamate receptor antibodies as an early biomarker of cerebral small vessel disease, Clinical Biochemistry, 10.1016/j.clinbiochem.2021.07.003, 96, (26-32), Online publication date: 1-Oct-2021. Hachinski V (2021) Brain Health—Curbing Stroke, Heart Disease, and Dementia, Neurology, 10.1212/WNL.0000000000012103, 97:6, (273-279), Online publication date: 10-Aug-2021. Dobrynina L, Shabalina A, Shamtieva K, Krotenkova M and Kalashnikova L (2021) Salt sensitivity and osmotic fragility are newly specified risk factors for age-related cerebral microangiopathy, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 10.17116/jnevro202112103177, 121:3, (77), . Capizzano A, Moritani T and Capizzano J (2021) Degenerative Diseases of the CNS Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine, 10.1007/978-3-030-62120-9_14, (353-389), . Dobrushina O, Arina G, Dobrynina L, Suslina A, Solodchik P, Belopasova A, Gubanova M, Sergeeva A, Kremneva E and Krotenkova M (2020) The ability to understand emotions is associated with interoception‐related insular activation and white matter integrity during aging, Psychophysiology, 10.1111/psyp.13537, 57:5, Online publication date: 1-May-2020. Davis S, Hacke W, Norrving B, Brainin M, Lees K and Donnan G (2020) International Impact of Stroke, Stroke, 51:3, (1036-1039), Online publication date: 1-Mar-2020. Zsoldos E, Mahmood A, Filippini N, Suri S, Heise V, Griffanti L, Mackay C, Singh-Manoux A, Kivimäki M and Ebmeier K (2020) Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study, Brain Communications, 10.1093/braincomms/fcaa026, 2:1, Online publication date: 1-Jan-2020. Gorelick P (2020) Vascular Cognitive Impairment Neurovascular Neuropsychology, 10.1007/978-3-030-49586-2_6, (121-138), . Puzo C, Labriola C, Sugarman M, Tripodis Y, Martin B, Palmisano J, Steinberg E, Stein T, Kowall N, McKee A, Mez J, Killiany R, Stern R and Alosco M (2019) Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set, Alzheimer's Research & Therapy, 10.1186/s13195-019-0521-0, 11:1, Online publication date: 1-Dec-2019. Brainin M, Feigin V, Bath P, Collantes E, Martins S, Pandian J, Sacco R and Teuschl Y (2019) Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization, International Journal of Stroke, 10.1177/1747493019873706, 14:8, (818-825), Online publication date: 1-Oct-2019. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan B, Sweeney M, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer C, Whitehead S, Black S, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M and Khachaturian Z (2019) Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto, International Journal of Stroke, 10.1177/1747493019871915, (174749301987191) Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan B, Sweeney M, Zlokovic B, Iturria‐Medina Y, Iadecola C, Nishimura N, Schaffer C, Whitehead S, Black S, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M and Khachaturian Z (2019) Preventing dementia by preventing stroke: The Berlin Manifesto, Alzheimer's & Dementia, 10.1016/j.jalz.2019.06.001, 15:7, (961-984), Online publication date: 1-Jul-2019. Hachinski V (2019) Dementia: Paradigm shifting into high gear, Alzheimer's & Dementia, 10.1016/j.jalz.2019.01.006, 15:7, (985-994), Online publication date: 1-Jul-2019. Cipollini V, Troili F and Giubilei F (2019) Emerging Biomarkers in Vascular Cognitive Impairment and Dementia: From Pathophysiological Pathways to Clinical Application, International Journal of Molecular Sciences, 10.3390/ijms20112812, 20:11, (2812) Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Suzuki J, Sasaki Y, Nagahama H, Hashi K, Kocsis J and Honmou O (2019) Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model, Neuroscience, 10.1016/j.neuroscience.2019.04.018, 408, (361-377), Online publication date: 1-Jun-2019. Hachinski V (2019) Dementia: new vistas and opportunities, Neurological Sciences, 10.1007/s10072-019-3714-1, 40:4, (763-767), Online publication date: 1-Apr-2019. Sweeney M, Zhao Z, Montagne A, Nelson A and Zlokovic B (2019) Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews, 10.1152/physrev.00050.2017, 99:1, (21-78), Online publication date: 1-Jan-2019. Sweeney M, Montagne A, Sagare A, Nation D, Schneider L, Chui H, Harrington M, Pa J, Law M, Wang D, Jacobs R, Doubal F, Ramirez J, Black S, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath P, Markus H, Al‐Shahi Salman R, Allan S, Quinn T, Kalaria R, Werring D, Carare R, Touyz R, Williams S, Moskowitz M, Katusic Z, Lutz S, Lazarov O, Minshall R, Rehman J, Davis T, Wellington C, González H, Yuan C, Lockhart S, Hughes T, Chen C, Sachdev P, O'Brien J, Skoog I, Pantoni L, Gustafson D, Biessels G, Wallin A, Smith E, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler M, Román G, Hamel E, Seshadri S, Gottesman R, Buchem M, Arvanitakis Z, Schneider J, Drewes L, Hachinski V, Finch C, Toga A, Wardlaw J and Zlokovic B (2019) Vascular dysfunction—The disregarded partner of Alzheimer's disease, Alzheimer's & Dementia, 10.1016/j.jalz.2018.07.222, 15:1, (158-167), Online publication date: 1-Jan-2019. Hachinski V (2018) The convergence of stroke and dementia, Arquivos de Neuro-Psiquiatria, 10.1590/0004-282x20180148, 76:12, (849-852) Hacke W and Hachinski V (2018) Response to the growing dementia burden must be broader, The Lancet Neurology, 10.1016/S1474-4422(18)30361-2, 17:11, (934), Online publication date: 1-Nov-2018. Gorelick P and Sorond F (2018) Vascular risk burden, brain health, and next steps, Neurology, 10.1212/WNL.0000000000006346, 91:16, (729-730), Online publication date: 16-Oct-2018. Hachinski V, Ganten D, Lackland D, Kreutz R, Tsioufis K and Hacke W (2018) Implementing the Proclamation of Stroke and Potentially Preventable Dementias, International Journal of Stroke, 10.1177/1747493018799965, 13:8, (780-786), Online publication date: 1-Oct-2018. Hachinski V, Ganten D, Lackland D, Kreutz R, Tsioufis K and Hacke W (2018) Implementing the proclamation of stroke and potentially preventable dementias, The Journal of Clinical Hypertension, 10.1111/jch.13382, 20:10, (1354-1359), Online publication date: 1-Oct-2018. Alladi S and Hachinski V (2018) World dementia, Neurology, 10.1212/WNL.0000000000005941, 91:6, (264-270), Online publication date: 7-Aug-2018. Kisler K, Lazic D, Sweeney M, Plunkett S, El Khatib M, Vinogradov S, Boas D, Sakadži´ S and Zlokovic B (2018) In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain, Nature Protocols, 10.1038/nprot.2018.034, 13:6, (1377-1402), Online publication date: 1-Jun-2018. Nucera A and Hachinski V (2018) Cerebrovascular and Alzheimer disease: fellow travelers or partners in crime?, Journal of Neurochemistry, 10.1111/jnc.14283, 144:5, (513-516), Online publication date: 1-Mar-2018. Gorelick P (2017) Prevention of cognitive impairment: scientific guidance and windows of opportunity, Journal of Neurochemistry, 10.1111/jnc.14113, 144:5, (609-616), Online publication date: 1-Mar-2018. Sweeney M, Sagare A and Zlokovic B (2018) Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders, Nature Reviews Neurology, 10.1038/nrneurol.2017.188, 14:3, (133-150), Online publication date: 1-Mar-2018. Montagne A, Nikolakopoulou A, Zhao Z, Sagare A, Si G, Lazic D, Barnes S, Daianu M, Ramanathan A, Go A, Lawson E, Wang Y, Mack W, Thompson P, Schneider J, Varkey J, Langen R, Mullins E, Jacobs R and Zlokovic B (2018) Pericyte degeneration causes white matter dysfunction in the mouse central nervous system, Nature Medicine, 10.1038/nm.4482, 24:3, (326-337), Online publication date: 1-Mar-2018. Gorelick P, Furie K, Iadecola C, Smith E, Waddy S, Lloyd-Jones D, Bae H, Bauman M, Dichgans M, Duncan P, Girgus M, Howard V, Lazar R, Seshadri S, Testai F, van Gaal S, Yaffe K, Wasiak H and Zerna C (2017) Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association, Stroke, 48:10, (e284-e303), Online publication date: 1-Oct-2017. Mestre H, Kostrikov S, Mehta R and Nedergaard M (2017) Perivascular spaces, glymphatic dysfunction, and small vessel disease, Clinical Science, 10.1042/CS20160381, 131:17, (2257-2274), Online publication date: 1-Sep-2017. Farooq M, Min J, Goshgarian C and Gorelick P (2017) Pharmacotherapy for Vascular Cognitive Impairment, CNS Drugs, 10.1007/s40263-017-0459-3, 31:9, (759-776), Online publication date: 1-Sep-2017. McHutchison C, Backhouse E, Cvoro V, Shenkin S and Wardlaw J (2017) Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life, Epidemiology, 10.1097/EDE.0000000000000675, 28:4, (608-618), Online publication date: 1-Jul-2017. Kisler K, Nelson A, Montagne A and Zlokovic B (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease, Nature Reviews Neuroscience, 10.1038/nrn.2017.48, 18:7, (419-434), Online publication date: 1-Jul-2017. Wu Y, Beiser A, Breteler M, Fratiglioni L, Helmer C, Hendrie H, Honda H, Ikram M, Langa K, Lobo A, Matthews F, Ohara T, Pérès K, Qiu C, Seshadri S, Sjölund B, Skoog I and Brayne C (2017) The changing prevalence and incidence of dementia over time — current evidence, Nature Reviews Neurology, 10.1038/nrneurol.2017.63, 13:6, (327-339), Online publication date: 1-Jun-2017. Li Z, Li J and Tang N (2017) Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression, Neuroscience, 10.1016/j.neuroscience.2017.04.017, 354, (1-10), Online publication date: 1-Jun-2017. Hachinski V (2017) Stoop to conquer: preventing stroke and dementia together, The Lancet, 10.1016/S0140-6736(17)30954-6, 389:10078, (1518), Online publication date: 1-Apr-2017. Shimizu A (2017) Genesis and the Risk Score of Atrial Fibrillation for Personalized Management, Circulation Journal, 10.1253/circj.CJ-17-0871, 81:11, (1574-1575), . Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels G, Fazekas F, Benavente O, Pantoni L, De Leeuw F, Norrving B, Matthews P, Chen C, Mok V, Düring M, Whiteley W, Shuler K, Alonso A, Black S, Brayne C, Chabriat H, Cordonnier C, Doubal F, Duzel E, Ewers M, Frayne R, Hachinski V, Ikram M, Jessen F, Jouvent E, Linn J, O'Brien J, Oostenbrugge R, Malik R, Mazoyer B, Schmidt R, Sposato L, Stephan B, Swartz R, Vernooij M, Viswanathan A, Werring D, Abe K, Allan L, Arba F, Diener H, Davis S, Hankey G, Lees K, Ovbiagele B, Weir C, Bae H, Bath P, Bordet R, Breteler M, Choi S, Deary I, DeCarli C, Ebmeier K, Feng L, Greenberg S, Ihara M, Kalaria R, Kim S, Lim J, Lindley R, Mead G, Murray A, Quinn T, Ritchie C, Sacco R, Al‐Shahi Salman R, Sprigg N, Sudlow C, Thomas A, Boxtel M, Grond J, Lugt A and Yang Y (2016) METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research, Alzheimer's & Dementia, 10.1016/j.jalz.2016.06.004, 12:12, (1235-1249), Online publication date: 1-Dec-2016. Wardlaw J and Horsburgh K (2016) Small vessels, dementia and chronic diseases–molecular mechanisms and pathophysiology, Clinical Science, 10.1042/CS20160376, 130:21, (1875-1879), Online publication date: 1-Nov-2016. Charidimou A and Viswanathan A (2016) Multiple neuropathologies and dementia in the aging brain: A key role for cerebrovascular disease?, Alzheimer's & Dementia: Translational Research & Clinical Interventions, 10.1016/j.trci.2016.11.001, 2:4, (281-282), Online publication date: 1-Nov-2016. Yan H, Yuan J, Gao L, Rao J and Hu J (2016) Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke, Neuroscience, 10.1016/j.neuroscience.2016.09.017, 337, (191-199), Online publication date: 1-Nov-2016. Shakir R, Davis S, Norrving B, Grisold W, Carroll W, Feigin V and Hachinski V (2016) Revising the ICD: stroke is a brain disease, The Lancet, 10.1016/S0140-6736(16)31850-5, 388:10059, (2475-2476), Online publication date: 1-Nov-2016. Hachinski V and Azarpazhooh M (2016) Stroke is a burdensome but preventable brain disorder, The Lancet Neurology, 10.1016/S1474-4422(16)30120-X, 15:9, (892-893), Online publication date: 1-Aug-2016. Brayne C and Wu Y (2016) Preventing both stroke and dementia – Authors' reply, The Lancet Neurology, 10.1016/S1474-4422(16)30042-4, 15:7, (659), Online publication date: 1-Jun-2016. Hachinski V, Sposato L and Kapral M (2016) Preventing both stroke and dementia, The Lancet Neurology, 10.1016/S1474-4422(16)30041-2, 15:7, (659), Online publication date: 1-Jun-2016. Corriveau R, Bosetti F, Emr M, Gladman J, Koenig J, Moy C, Pahigiannis K, Waddy S and Koroshetz W (2016) The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline, Cellular and Molecular Neurobiology, 10.1007/s10571-016-0334-7, 36:2, (281-288), Online publication date: 1-Mar-2016. Michel P (2016) Stroke, Current Opinion in Neurology, 10.1097/WCO.0000000000000291, 29:1, (1-3), Online publication date: 1-Feb-2016. Gorelick P (2015) World Stroke Day Proclamation 2015, Stroke, 46:11, (3037-3038), Online publication date: 1-Nov-2015.Related articlesCorrectionStroke. 2016;47:e18-e18CorrectionStroke. 2016;47:e37-e37 November 2015Vol 46, Issue 11 Advertisement Article InformationMetrics © 2015 by the American Heart Association, Inc., and the World Stroke Organization.https://doi.org/10.1161/STROKEAHA.115.011237PMID: 26504189 Originally publishedNovember 1, 2015 PDF download Advertisement SubjectsCardiopulmonary Resuscitation and Emergency Cardiac Care

Referência(s)
Altmetric
PlumX