Therapeutic interventions for disease progression in Huntington's disease
2009; Elsevier BV; Linguagem: Inglês
10.1002/14651858.cd006455.pub2
ISSN1465-1858
AutoresTiago Mestre, Joaquim J. Ferreira, Miguel Coelho, Màrio Miguel Rosa, Cristina Sampaio,
Tópico(s)Mitochondrial Function and Pathology
ResumoHuntington's disease (HD) is an autosomal dominant neurodegenerative disease with an average onset between the fourth and fifth decade of life; it leads to death 15 to 20 years after the onset of symptoms. Although several drugs seem effective in controlling the incapacitating manifestations of HD, no specific therapy is known. The present review aims at analysing the best available data on therapeutic interventions investigated with the goal of modifying the progression of the disease as measured in terms of survival, disability or progression of HD core symptoms.
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