Virulence of Six Strains of Mycobacterium bovis (BCG) in Mice
1973; American Society for Microbiology; Volume: 8; Issue: 5 Linguagem: Inglês
10.1128/iai.8.5.736-742.1973
ISSN1098-5522
AutoresNeal A. Sher, S D Chaparas, Jack W. Pearson, Michael A. Chirigos,
Tópico(s)Mycobacterium research and diagnosis
ResumoThe abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF 1 male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.
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