Voltar
Artigo Revisado por pares
BIBTEX RIS

Labelling of [Leu5]-enkephalin with organometallic Mo complexes by solid-phase synthesisElectronic supplementary information (ESI) available: full analytical data for 2–4. See http://www.rsc.org/suppdata/cc/b2/b203128k/Abbreviations: HMBA = hydroxymethylbenzoic acid; 2-Cl-Trt = 2-chlorotrityl; TFA = trifluoroacetic acid; TIS = triisopropylsilane; TBTU = O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; Enk = leucine-enkephalin, [Leu5]-enkephalin; HOBt = …

2002; Royal Society of Chemistry; Issue: 13 Linguagem: Inglês

10.1039/b203128k

ISSN

1364-548X

Autores

Dave R. van Staveren, Nils Metzler‐Nolte,

Tópico(s)

Peptidase Inhibition and Analysis

Resumo

The neuropeptide leucine-enkephalin ([Leu5]-enkephalin) has been covalently labelled with the two organometallic Mo carbonyl complexes Mo(R-His)(allyl)(CO)2 (His = Nδ,N,O-L-histidinate) and Mo(R-bpa)(CO)3 (bpa = bis(2-picolyl)amine) on the resin as the last step of a solid-phase synthesis scheme and in solution.

Referência(s)