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Kidney function estimating equations in patients with chronic kidney disease

2011; Wiley; Volume: 65; Issue: 4 Linguagem: Inglês

10.1111/j.1742-1241.2010.02597.x

1742-1241

Radovan Hojs, Sebastjan Bevc, Robert Ekart, Maksimiljan Gorenjak, Ludvik Puklavec,

Renal and Vascular Pathologies

International Journal of Clinical PracticeVolume 65, Issue 4 p. 458-464 ORIGINAL PAPER Kidney function estimating equations in patients with chronic kidney disease R. Hojs, R. Hojs Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorS. Bevc, S. Bevc Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorR. Ekart, R. Ekart Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorM. Gorenjak, M. Gorenjak Department of Clinical Chemistry, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorL. Puklavec, L. Puklavec Department of Nuclear Medicine, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this author R. Hojs, R. Hojs Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorS. Bevc, S. Bevc Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorR. Ekart, R. Ekart Department of Nephrology, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorM. Gorenjak, M. Gorenjak Department of Clinical Chemistry, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this authorL. Puklavec, L. Puklavec Department of Nuclear Medicine, Clinic of Internal Medicine, University Medical center Maribor, Maribor, SloveniaSearch for more papers by this author First published: 15 March 2011 https://doi.org/10.1111/j.1742-1241.2010.02597.xCitations: 19 Sebastjan Bevc, MD, PhD, Univerzitetni klinični center Maribor, Klinika za interno medicino, Oddelek za nefrologijo, Ljubljanska 5, 2000 Maribor, SloveniaTel.: + 386 2 321 2871Fax: + 386 2 3312 393Email: [email protected] Disclosures None declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Summary Background: The current guidelines emphasise the need to assess kidney function using predictive equations rather than just serum creatinine. The present study compares serum cystatin C-based equations and serum creatinine-based equations in patients with chronic kidney disease (CKD). Methods: Seven hundred and sixty-four adult patients with CKD were enrolled. In each patient serum creatinine and serum cystatin C were determined. Their glomerular filtration rate (GFR) was estimated using three serum creatinine-based equations [Cockcroft–Gault (C&G), modification of diet in renal disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI)] and two serum cystatin C-based equations [our own cystatin C formula (GFR = 90.63 × cystatin C−1.192) and simple cystatin C formula (GFR = 100/cystatin C)]. The GFR was measured using 51CrEDTA clearance. Results: Statistically significant correlation between 51CrEDTA clearance with serum creatinine, serum cystatin C and all observed formulas was found. The receiver operating characteristic curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C and both cystatin C formulas had a higher diagnostic accuracy than C&G formula. Bland and Altman analysis for the same cut-off value showed that all formulas except simple cystatin C formula underestimated measured GFR. The accuracy within 30% of estimated 51CrEDTA clearance values differs according to stages of CKD. Analysis of ability to correctly predict patient's GFR below or above 60 ml/min/1.73 m2 showed statistically significant higher ability for both cystatin C formulas compared to MDRD formula. Conclusion: Our results indicate that serum cystatin C-based equations are reliable markers of GFR comparable with creatinine-based formulas. Citing Literature Volume65, Issue4April 2011Pages 458-464 RelatedInformation