Produção Nacional
Revisado por pares
CD44+/CD133+ immunophenotype and matrix metalloproteinase‐9: Influence on prognosis in early‐stage oral squamous cell carcinoma
2013; Wiley; Volume: 36; Issue: 12 Linguagem: Inglês
10.1002/hed.23527
ISSN1097-0347
AutoresLucinei Roberto Oliveira, Andrielle Castilho–Fernandes, João Paulo Oliveira–Costa, Fernando Augusto Soares, Sérgio Zucoloto, Alfredo Ribeiro‐Silva,
Tópico(s)Cancer Cells and Metastasis
ResumoABSTRACT Background The purpose of this study was to investigate the expression of CD44 and/or CD133 immunophenotypes and the associated effects of matrix metalloproteinase‐9 (MMP‐9) in early‐stage oral squamous cell carcinomas (SCC) to assess their influence on tumor prognosis. Methods The following data were derived from 150 patients: age, sex, primary anatomic site, smoking status, alcohol intake, recurrence, metastases, histological classification, treatment, disease‐free survival (DFS), and overall survival (OS). Immunohistochemical study of CD44, CD133, and MMP‐9 expression was performed on a tissue microarray of 150 paraffin blocks of oral SCCs. Results The predominant immunophenotype identified to exhibit a significant correlation with MMP‐9 was the CD44+/CD133+. Multivariate analyses identified a significant correlation of OS with surgical treatment and with CD44+/CD133+ immunophenotype. Conclusion This investigation demonstrated the prognostic importance of CD44/CD133 expression, which can help improve the prognostic value of surgical treatment for oral SCCs when diagnosed in early stages. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1718–1726, 2014
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