Produção Nacional
Prevalência da infecção pelos vírus da hepatite B (VHB) e da hepatite Delta (VHD) em Lábrea, Rio Purus, Estado do Amazonas
2004; MINISTÉRIO DA SAÚDE; Volume: 13; Issue: 1 Linguagem: Inglês
10.5123/s1679-49742004000100005
ISSN2237-9622
AutoresWornei Silva Miranda Braga, Leila Melo Brasil, Rita Auxiliadora Botelho de Souza, Marilene Sabóia de Melo, Maria Dolores Gomes Rosas, Márcia da Costa Castilho, José Carlos Ferraz da Fonseca,
Tópico(s)HIV/AIDS Research and Interventions
ResumoSummary This study estimates the prevalence of hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infections in the city of Labrea, Western Amazon, Brazil, 11 years after the introduction of the HBV vaccination program in this region. The prevalence rates of HBV infection and HBV surface antigen (HbsAg) carriage were 49,9% and 3,3% respectively. HBV infection shows a medium endemicity pattern, low potential of infectivity and subclinical course of infection. Transmission may be more intense in children between 6 and 12 years of age, and among young adults, probably by perinatal or horizontal transmission within households or by sexual transmission, with a moderate risk for the development of chronic liver disorders. Interfamilial dissemination may be of great importance. HDV was found in 30% of HBsAg carriers, occurred with a history of acute hepatitis, and in HBV carriers was associated with biochemical signs of liver damage, demonstrating the importance of these two viruses as agents of liver disease in this population. We identified a significant reduction in the prevalence rates of HBV infection compared to those reported before the
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