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PROOF OF PRINCIPLE OF OCULAR SPARING IN DOGS WITH SINONASAL TUMORS TREATED WITH INTENSITY-MODULATED RADIATION THERAPY

2010; Wiley; Volume: 51; Issue: 5 Linguagem: Inglês

10.1111/j.1740-8261.2010.01695.x

1740-8261

Jessica Lawrence, Lisa J. Forrest, Michelle Turek, P. Elliott Miller, T. Rockwell Mackie, H. Jaradat, David M. Vail, Richard R. Dubielzig, Richard J. Chappell, Minesh P. Mehta,

Salivary Gland Tumors Diagnosis and Treatment

Veterinary Radiology & UltrasoundVolume 51, Issue 5 p. 561-570 PROOF OF PRINCIPLE OF OCULAR SPARING IN DOGS WITH SINONASAL TUMORS TREATED WITH INTENSITY-MODULATED RADIATION THERAPY JESSICA A. LAWRENCE, JESSICA A. LAWRENCE School of Veterinary Medicine, Department of Medical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorLISA J. FORREST, LISA J. FORREST Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706 The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorMICHELLE M. TUREK, MICHELLE M. TUREK Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorPAUL E. MILLER, PAUL E. MILLER Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorT. ROCKWELL MACKIE, T. ROCKWELL MACKIE The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Human Oncology, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 TomoTherapy Inc., 1430 Deming Way, Madison, WI 53717Search for more papers by this authorHAZIM A. JARADAT, HAZIM A. JARADAT Department of Human Oncology, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorDAVID M. VAIL, DAVID M. VAIL School of Veterinary Medicine, Department of Medical Sciences, 2015 Linden Drive, Madison, WI 53706 The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorRICHARD R. DUBIELZIG, RICHARD R. DUBIELZIG Department of Pathobiological Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorRICHARD CHAPPELL, RICHARD CHAPPELL The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 School of Medicine and Public Health, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorMINESH P. MEHTA, MINESH P. MEHTA The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this author JESSICA A. LAWRENCE, JESSICA A. LAWRENCE School of Veterinary Medicine, Department of Medical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorLISA J. FORREST, LISA J. FORREST Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706 The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorMICHELLE M. TUREK, MICHELLE M. TUREK Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorPAUL E. MILLER, PAUL E. MILLER Department of Surgical Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorT. ROCKWELL MACKIE, T. ROCKWELL MACKIE The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Human Oncology, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 TomoTherapy Inc., 1430 Deming Way, Madison, WI 53717Search for more papers by this authorHAZIM A. JARADAT, HAZIM A. JARADAT Department of Human Oncology, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorDAVID M. VAIL, DAVID M. VAIL School of Veterinary Medicine, Department of Medical Sciences, 2015 Linden Drive, Madison, WI 53706 The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorRICHARD R. DUBIELZIG, RICHARD R. DUBIELZIG Department of Pathobiological Sciences, 2015 Linden Drive, Madison, WI 53706Search for more papers by this authorRICHARD CHAPPELL, RICHARD CHAPPELL The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 School of Medicine and Public Health, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this authorMINESH P. MEHTA, MINESH P. MEHTA The Paul P. Carbone Comprehensive Cancer Center, Department of Medical Physics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705Search for more papers by this author First published: 02 September 2010 https://doi.org/10.1111/j.1740-8261.2010.01695.xCitations: 58 Address correspondence and reprint requests to Lisa J. Forrest, at the above address. E-mail: lforrest@wisc.edu Notification of conflict of interest: T. Rockwell Mackie, PhD, is cofounder of TomoTherapy Inc., chairman of the board, and director of research. Minesh P. Mehta, MD is a paid consultant for TomoTherapy, Inc. Both have a financial interest in that company.Funding support provided by: NIH P01 CA088960.Data presented in part: 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia PA, November 5–9, 2006. Jessica A. Lawrence's and Michelle M. Turek's present address is College of Veterinary Medicine, University of Georgia, Athens, GA 30602. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Intensity-modulated radiation therapy (IMRT) allows optimization of radiation dose delivery to complex tumor volumes with rapid dose drop-off to surrounding normal tissues. A prospective study was performed to evaluate the concept of conformal avoidance using IMRT in canine sinonasal cancer. The potential of IMRT to improve clinical outcome with respect to acute and late ocular toxicity was evaluated. Thirty-one dogs with sinonasal cancer were treated definitively with IMRT using helical tomotherapy and/or dynamic multileaf collimator (DMLC) delivery. Ocular toxicity was evaluated prospectively and compared with a comparable group of historical controls treated with conventional two-dimensional radiotherapy (2D-RT) techniques. Treatment plans were devised for each dog using helical tomotherapy and DMLC that achieved the target dose to the planning treatment volume and limited critical normal tissues to the prescribed dose–volume constraints. Overall acute and late toxicities were limited and minor, detectable by an experienced observer. This was in contrast to the profound ocular morbidity observed in the historical control group treated with 2D-RT. Overall median survival for IMRT-treated and 2D-treated dogs was 420 and 411 days, respectively. Compared with conventional techniques, IMRT reduced dose delivered to eyes and resulted in bilateral ocular sparing in the dogs reported herein. These data provide proof-of-principle that conformal avoidance radiotherapy can be delivered through high conformity IMRT, resulting in decreased normal tissue toxicity as compared with historical controls treated with 2D-RT. Citing Literature Volume51, Issue5September/October 2010Pages 561-570 RelatedInformation