The chromosomal 3',5"-aminoglycoside phosphotransferase in Streptococcus pneumoniae is closely related to its plasmid-coded homologs in Streptococcus faecalis and Staphylococcus aureus
1983; American Society for Microbiology; Volume: 156; Issue: 3 Linguagem: Inglês
10.1128/jb.156.3.1373-1377.1983
ISSN1098-5530
AutoresE. Collatz, C Carlier, Patrice Courvalin,
Tópico(s)RNA and protein synthesis mechanisms
ResumoThe apparently chromosomally encoded 3',5"-aminoglycoside phosphotransferase (type III), from the high-level aminoglycoside-resistant Streptococcus pneumoniae BM4200, was compared with homologous enzymes coded for by the plasmids pJH1 and pSH2, originally isolated from Streptococcus faecalis and Staphylococcus aureus, respectively, and also found in a wild strain of S. aureus, BM4600. The enzymes appeared to be indistinguishable, and we conclude that the gene encoding 3',5"-aminoglycoside phosphotransferase (type III) can cross generic barriers within gram-positive cocci.
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