Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma
2014; Wiley; Volume: 110; Issue: 4 Linguagem: Inglês
10.1002/jso.23672
ISSN1096-9098
AutoresChang Hwan Ryu, Junsun Ryu, Kwan Ho Cho, Sung Ho Moon, Tak Yun, Sang‐Hyun Lee, Moon Kyung Choi, Weon Seo Park, Yuh‐S. Jung,
Tópico(s)Salivary Gland Tumors Diagnosis and Treatment
ResumoJournal of Surgical OncologyVolume 110, Issue 4 p. 393-399 Research Article Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma Chang Hwan Ryu MD, Chang Hwan Ryu MD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorJunsun Ryu MD, PhD, Junsun Ryu MD, PhD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorKwan Ho Cho MD, PhD, Kwan Ho Cho MD, PhD Center for Proton Therapy, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorSung Ho Moon MD, PhD, Sung Ho Moon MD, PhD Center for Proton Therapy, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorTak Yun MD, PhD, Tak Yun MD, PhD Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorSang-Hyun Lee MD, PhD, Sang-Hyun Lee MD, PhD Department of Radiology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorMoon Kyung Choi MS, Moon Kyung Choi MS Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorWeon Seo Park MD, PhD, Corresponding Author Weon Seo Park MD, PhD Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea Correspondence to: Weon Seo Park, MD, PhD, Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: thymus@ncc.re.kr Correspondence to: Yuh-S. Jung, MD, PhD, Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: jysorl@ncc.re.krSearch for more papers by this authorYuh-S. Jung MD, PhD, Corresponding Author Yuh-S. Jung MD, PhD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea Correspondence to: Weon Seo Park, MD, PhD, Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: thymus@ncc.re.kr Correspondence to: Yuh-S. Jung, MD, PhD, Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: jysorl@ncc.re.krSearch for more papers by this author Chang Hwan Ryu MD, Chang Hwan Ryu MD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorJunsun Ryu MD, PhD, Junsun Ryu MD, PhD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorKwan Ho Cho MD, PhD, Kwan Ho Cho MD, PhD Center for Proton Therapy, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorSung Ho Moon MD, PhD, Sung Ho Moon MD, PhD Center for Proton Therapy, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorTak Yun MD, PhD, Tak Yun MD, PhD Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorSang-Hyun Lee MD, PhD, Sang-Hyun Lee MD, PhD Department of Radiology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorMoon Kyung Choi MS, Moon Kyung Choi MS Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, KoreaSearch for more papers by this authorWeon Seo Park MD, PhD, Corresponding Author Weon Seo Park MD, PhD Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea Correspondence to: Weon Seo Park, MD, PhD, Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: thymus@ncc.re.kr Correspondence to: Yuh-S. Jung, MD, PhD, Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: jysorl@ncc.re.krSearch for more papers by this authorYuh-S. Jung MD, PhD, Corresponding Author Yuh-S. Jung MD, PhD Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea Correspondence to: Weon Seo Park, MD, PhD, Hematologic Malignancy Branch, Department of Pathology, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: thymus@ncc.re.kr Correspondence to: Yuh-S. Jung, MD, PhD, Specific Organs Cancer Branch, Department of Otolaryngology, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. Fax: +82-31-920-1275. E-mail: jysorl@ncc.re.krSearch for more papers by this author First published: 05 June 2014 https://doi.org/10.1002/jso.23672Citations: 6 The authors have no conflicts of interest to declare. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objectives To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). Patients and Methods Immunohistochemical profiles of HPV-related cell cycle markers, including p16, pRb, cyclin D1, p53, and the HPV DNA status of 42 consecutive TSCC patients who underwent TLO-based treatments were analyzed. The prognostic value of each marker was evaluated. Results Univariate analysis indicated that high p16, low pRb, and low p53 expression levels are significantly associated with a good disease-free and overall survival outcome. Clinicopathological parameters and the HPV DNA status did not show prognostic significance. When adjusted for age, overall stage and treatment strategy, a high p16 and low pRb level remained an effective prognostic marker for good survival outcomes. A high p16/low pRb combination showed superior survival prediction ability over high p16 or low pRb alone. Conclusion HPV-related cell cycle markers may also be good indicators for predicting survival after TLO for TSCC. The de-escalation TLO surgery approach would be more effective if performed under the stringent guidance of these markers. J. Surg. Oncol. 2014; 110:393–399. © 2014 Wiley Periodicals, Inc. Citing Literature Volume110, Issue4September 15, 2014Pages 393-399 RelatedInformation
Referência(s)