Role of Phospholipase-Associated Penetration Mechanism in Cell Injury by Rickettsia rickettsii
1983; American Society for Microbiology; Volume: 40; Issue: 2 Linguagem: Inglês
10.1128/iai.40.2.840-842.1983
ISSN1098-5522
AutoresDavid H. Walker, William T. Firth, J. Glen Ballard, Barbara C. Hegarty,
Tópico(s)Botanical Research and Chemistry
ResumoThe cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.
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