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BIBTEX RIS

Polysaccharide fraction isolated from P assiflora edulis inhibits the inflammatory response and the oxidative stress in mice

2015; Oxford University Press; Volume: 67; Issue: 7 Linguagem: Inglês

10.1111/jphp.12399

2042-7158

Renan O. Silva, Samara Damasceno, Tarcísio Vieira de Brito, Jordana Maia Dias, Amanda M Fontenele, Isabela S Braúna, José Simião C. Júnior, Jeanny S. Maciel, Regina C.M. de Paula, Ronaldo A. Ribeiro, Marcellus Henrique Loiola Ponte de Souza, Ana Lúcia Ponte Freitas, Jand Venes Rolim Medeiros, Draulio C. Silva, André Luiz dos Reis Barbosa,

Phytochemistry and Biological Activities

The aim of the study was to investigate the anti-inflammatory, antioxidant and antinociceptive actions of PFPe, a polysaccharide fraction isolated from the dried fruit of the Passiflora edulis.Animals were pretreated with PFPe (0.3, 1 or 3 mg/kg, i.p.) 1 h before induction of paw oedema by carrageenan, histamine, serotonin, compound 48/80 or prostaglandin E2 (PGE2). Neutrophil migration and vascular permeability were measured after carrageenan injection into the peritoneum, and the action of the PFPe on the tumour necrosis factor-alpha, interleukin-1 beta (IL-1β), myeloperoxidase (MPO), glutathione (GSH) and malondialdehyde (MDA) levels was also evaluated. To assay nociception, we examined acetic acid-induced writhing, formalin-induced paw licking and response latency in the hot plate test.Pretreatment with PFPe significantly inhibited carrageenan-induced paw oedema. PFPe also reduced paw oedema induced by compound 48/80, histamine, serotonin, and PGE2 and compound 48/80-induced vascular permeability. In addition, PFPe significantly reduced the MPO activity, MDA and GSH concentrations, and IL-1β level. In the nociception tests, PFPe reduced acetic acid-induced writhing and formalin-induced paw licking and did not increase the response latency time.Our results suggest that PFPe administration reduces the inflammatory response by modulation of the liberation or synthesis of histamine and serotonin, by reduction of neutrophil migration, IL-1β levels, and oxidative stress and nociception.