Produção Nacional
Revisado por pares
Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis
2011; Springer Science+Business Media; Volume: 21; Issue: 4 Linguagem: Inglês
10.1590/s0102-695x2011005000116
ISSN1981-528X
AutoresRodney Alexandre Ferreira Rodrigues, João Ernesto de Carvalho, Ilza Maria de Oliveira Sousa, Márcia Aparecida Antônio, Paulo Eduardo Pizão, Luciana K. Kohn, Maria do Carmo Estanislau do Amaral, Volker Bittrich, Mary Ann Foglio,
Tópico(s)Phytochemical compounds biological activities
ResumoGaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 µg/mL. FC was further fractionated affording isolated compound 2β, 3β-dihydroxy-urs-12-ene-28-oic acid , identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines.
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