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BIBTEX RIS

Sinais de proliferação via regulação de histona H3 em modelo in vitro de linfoproliferação

2007; Elsevier BV; Volume: 29; Issue: 4 Linguagem: Inglês

10.1590/s1516-84842007000400023

ISSN

1806-0870

Autores

Karla B.C. Menditi,

Tópico(s)

T-cell and Retrovirus Studies

Resumo

presented at well-defined points in time for proliferation and apoptosis of from 72 to 96 hours and 96 to 120 hours, respectively.In these cells, the profiles of acetylation and phosphorilation of histone H3 slightly resemble the growth curve, but methylation increased at each time point.The growth curve of Jurkat cells showed an increase in the number of cells at all time points, however, we observed no changes in Histone H3 modifications.These findings suggest that epigenetic mechanisms are involved in neoplasic transformation and result in a decrease in the histone H3 methylation profile of leukemic lymphocytes.

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