Stimulation of human lymphocytes by Herpes simplex virus antigens
1975; American Society for Microbiology; Volume: 11; Issue: 1 Linguagem: Inglês
10.1128/iai.11.1.109-112.1975
ISSN1098-5522
AutoresStuart E. Starr, Siraj A Karatela, Steven L. Shore, ANTOINETTE DUFFEY, André J. Nahmias,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoLymphocytes from individuals with laboratory evidence of prior infection with herpes simplex virus (HSV) type 1 or type 2 demonstrated transformation (av antigens. Higher stimulation indexes were obtained when lymphocytes were incubated with the homologous as compared with the heterologous antigen. Higher mean lymphocyte stimulation indexes were also demonstrated in seropositive as compared with seronegative individuals. Lymphocytes from children with HSV-1 stomatitis usually became responsive to HSV-1 antigen within 2 to 6 weeks after the onset of illness. Lymphocytes from infants with neonatal HSV-2 infection were stimulated by HSV-2 antigen.
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