An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium‐Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution
2015; Wiley; Volume: 2015; Issue: 27 Linguagem: Inglês
10.1002/ejoc.201500661
ISSN1434-193X
AutoresMarc Perez, Pierre‐Georges Echeverria, E. Martinez-Arripe, Mehdi Ez Zoubir, Ridha Touati, Zhaoguo Zhang, Jean‐Pierre Genêt, Phannarath Phansavath, Tahar Ayad, Virginie Ratovelomanana‐Vidal,
Tópico(s)Chemical Reactions and Isotopes
ResumoAbstract Thiamphenicol is a widely used antibiotic that exhibits activity against numerous Gram‐positive and Gram‐negative pathogens. Here, we describe the expedient synthesis of its four stereoisomers through a dynamic kinetic resolution that follows a ruthenium‐catalyzed asymmetric hydrogenation or a hydrogen transfer reaction as the key step.
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