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Association between baseline fetal hemoglobin levels and incidence of severe vaso‐occlusive pain episodes in children with sickle cell anemia

2013; Wiley; Volume: 60; Issue: 10 Linguagem: Inglês

10.1002/pbc.24588

1545-5017

Pallav Bhatnagar, Jeffrey R. Keefer, James F. Casella, Emily Barron‐Casella, Christopher J. Bean, Craig Hooper, Amanda B. Payne, Dan E. Arking, Michael R. DeBaun,

Prenatal Screening and Diagnostics

Abstract The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well‐known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta‐analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization ( P ‐value = 0.02). Pediatr Blood Cancer 2013;60:E125–E127. © 2013 Wiley Periodicals, Inc.