Produção Nacional
Revisado por pares
HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis
2010; Wiley; Volume: 18; Issue: 4 Linguagem: Inglês
10.1111/j.1468-1331.2010.03109.x
ISSN1468-1331
AutoresAndreia Bettencourt, A. M. Silva, Ernestina Santos, Saint Clair Gomes, Denisa Mendonça, Paulo Costa, Paula Faustino, Berta Martins da Silva,
Tópico(s)Restless Legs Syndrome Research
ResumoEuropean Journal of NeurologyVolume 18, Issue 4 p. 663-666 SHORT COMMUNICATION HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis A. Bettencourt, A. Bettencourt UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto These authors contributed equally to this work.Search for more papers by this authorA. M. Silva, A. M. Silva UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto Centro Hospitalar do Porto – Hospital de Santo António, Porto These authors contributed equally to this work.Search for more papers by this authorE. Santos, E. Santos Centro Hospitalar do Porto – Hospital de Santo António, PortoSearch for more papers by this authorS. Gomes, S. Gomes Instituto Nacional de Saúde Dr. Ricardo Jorge, LisboaSearch for more papers by this authorD. Mendonça, D. Mendonça Instituto de Saúde Pública – Universidade do Porto, Porto Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), PortoSearch for more papers by this authorP. P. Costa, P. P. Costa UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, PortugalSearch for more papers by this authorP. Faustino, P. Faustino Instituto Nacional de Saúde Dr. Ricardo Jorge, LisboaSearch for more papers by this authorB. M. Silva, B. M. Silva UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), PortoSearch for more papers by this author A. Bettencourt, A. Bettencourt UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto These authors contributed equally to this work.Search for more papers by this authorA. M. Silva, A. M. Silva UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto Centro Hospitalar do Porto – Hospital de Santo António, Porto These authors contributed equally to this work.Search for more papers by this authorE. Santos, E. Santos Centro Hospitalar do Porto – Hospital de Santo António, PortoSearch for more papers by this authorS. Gomes, S. Gomes Instituto Nacional de Saúde Dr. Ricardo Jorge, LisboaSearch for more papers by this authorD. Mendonça, D. Mendonça Instituto de Saúde Pública – Universidade do Porto, Porto Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), PortoSearch for more papers by this authorP. P. Costa, P. P. Costa UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, PortugalSearch for more papers by this authorP. Faustino, P. Faustino Instituto Nacional de Saúde Dr. Ricardo Jorge, LisboaSearch for more papers by this authorB. M. Silva, B. M. Silva UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), PortoSearch for more papers by this author First published: 16 March 2011 https://doi.org/10.1111/j.1468-1331.2010.03109.xCitations: 7 A. Bettencourt, UMIB – Instituto de Ciências Biomédicas Abel Salazar (ICBAS – UPorto), Largo Prof. Abel Salazar, 2, 4099-003 Porto, Portugal (tel.: +351222062255; fax: +351222062232; e-mail: ambettencourt@icbas.up.pt). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background: High iron concentrations have been reported in oligodendrocytes, myelin and macrophages in multiple sclerosis (MS) lesions. It has been proposed that HFE gene polymorphisms could have a role in MS. Methods: The C282Y and H63D HFE variants frequencies were determined in 373 patients with MS and compared with a normal population. Results: No significant association was found between HFE polymorphisms and disease susceptibility. An analysis of the association of genotypes with disease severity was performed, and the C282Y allele was more frequent in the aggressive group. Conclusions: Patients carrying the C282Y variant seem to have a worse prognosis. Citing Literature Supporting Information Figure S1. Survival probability of patients having reached an EDSS = 6 after stratification according to the presence of C282Y. Table S1. Case processing summary. Table S2. Means and medians for survival time. Table S3. Overall comparisons. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. Filename Description ENE_3109_sm_supmat.doc103 KB Supporting info item Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume18, Issue4April 2011Pages 663-666 RelatedInformation
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