Portal de Periódicos da CAPES

Present and future therapies of hepatitis B: From discovery to cure

2015; Lippincott Williams & Wilkins; Volume: 62; Issue: 6 Linguagem: Inglês

10.1002/hep.28025

1527-3350

T. Jake Liang, Timothy M. Block, Brian J. McMahon, Marc G. Ghany, Stephan Urban, Ju‐Tao Guo, Stephen Locarnini, Fabien Zoulim, Kyong–Mi Chang, Anna S. Lok,

Liver Disease Diagnosis and Treatment

Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase, and we will likely see more of them moving along the development pipeline.With growing interest in developing and efforts to develop more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.