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Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test

2006; Springer Science+Business Media; Volume: 16; Issue: 1 Linguagem: Inglês

10.1590/s0102-695x2006000100003

1981-528X

Suzana Guimarães Leitão, Oscar Castro, Eduardo Nunes da Fonseca, Lisieux S. Julião, Eliana Schwartz Tavares, Rodrigo R. T. Leo, Ricardo Cardoso Vieira, Danilo Ribeiro de Oliveira, Gilda Guimarães Leitão, Virginia S. Martino, Valeria P. Sülsen, Ymira A.G. Barbosa, Diva P.G. Pinheiro, Pedro Eduardo Almeida da Silva, Dulcinéia Furtado Teixeira, N. Ivan, Maria Cristina S. Lourenço,

Phytochemistry and Biological Activities

Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.