Reconstruction and Simulation of Neocortical Microcircuitry
2015; Cell Press; Volume: 163; Issue: 2 Linguagem: Inglês
10.1016/j.cell.2015.09.029
ISSN1097-4172
AutoresHenry Markram, Eilif Müller, Srikanth Ramaswamy, Michael W. Reimann, Marwan Abdellah, Carlos Sanchez, Anastasia Ailamaki, Lidia Alonso‐Nanclares, Nicolas Antille, Selim Arsever, Guy Antoine Atenekeng Kahou, Thomas K. Berger, Ahmet Bilgili, Nenad Buncic, Athanassia Chalimourda, Giuseppe Chindemi, Jean-Denis Courcol, Fabien Delalondre, Vincent Delattre, Shaul Druckmann, Raphael Dumusc, J.A. Dynes, Stefan Eilemann, Eyal Gal, Michael Gevaert, Jean-Pierre Ghobril, Albert Gidon, Joe W. Graham, Anirudh Gupta, Valentin Haenel, Etay Hay, Thomas Heinis, Juan Hernando, Michael L. Hines, Lida Kanari, Daniel Keller, John Kenyon, Georges Khazen, Yihwa Kim, James King, Zoltán F. Kisvárday, Pramod Kumbhar, Sébastien Lasserre, Jean-Vincent Le Bé, Bruno R. C. Magalhães, Angel Merchàn‐Pérez, Julie Meystre, Benjamin Roy Morrice, Jeffrey Muller, Alberto Muñoz, Shruti Muralidhar, Keerthan Muthurasa, Daniel Nachbaur, Taylor Newton, Max Nolte, Aleksandr Ovcharenko, Juan C. Palacios, Luis Pastor, Rodrigo Perin, Rajnish Ranjan, Imad Riachi, José-Rodrigo Rodrı́guez, Juan Luis Riquelme, Christian Rössert, Konstantinos Sfyrakis, Ying Shi, Julian C. Shillcock, Gilad Silberberg, Ricardo Silva, Farhan Tauheed, Martin Telefont, Maria Toledo‐Rodriguez, Thomas Tränkler, Werner Van Geit, Jafet Villafranca Díaz, Richard Walker, Yun Wang, Stefano M. Zaninetta, Javier DeFelipe, Sean Hill, Idan Segev, Felix Schürmann,
Tópico(s)Neuroscience and Neural Engineering
ResumoWe present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.PaperClip/cms/asset/5c91a1a4-b7e0-4955-9798-ad9ab0d5fbaa/mmc9.mp3Loading ...(mp3, 4.69 MB) Download audio Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJiYzRhNjA2YjExNzIyYzdkYTg3ZWE3NmE3ZTk2ZjFhOSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NTQxODAyfQ.EjLkN-IdxBeFQwOHLTNE-2eF9J6Lj0To4SrjSD3lMLMRJI3tlaCZjGO7CWvJIuPRild2x9HPTykK5VTweD2086IAqwaIX88_9L6vL1nSl-IjX9XmcnyPPjGqdTDbyhUKNI8rY0XP4lJjVIq9nK7oUQGMDTc-xpohB3YpbptwG2nf_1S1Qy-X9V9BiAjFKz9aRCoJXxNgMXzLHwMMZGBD5AXohicEJA97wt7mjd40e9zGmhGhWTtJLIjdX2oedpNmxDqbApsvVd5uG1F4Z4vHnJQ5Agc77dB0lXhZW_HE-RO-Gr6SWKd7D4ErXyWzchsflW6zaVdNBUhQ_DxLeFJ9lg(mp4, (24.73 MB) Download video
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