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Hybrid Resistance to Parental DBA/2 Grafts: Independence From the <italic>H-2</italic> Locus. II. Studies With Friend Virus-Induced Leukemia Cells<xref ref-type="fn" rid="FN2">2</xref>

1972; Oxford University Press; Linguagem: Inglês

10.1093/jnci/48.4.997

1460-2105

Gustavo Cudkowicz, Giovanni Battista Rossi, Jamil R. Haddad, Charlotte Friend,

Mesenchymal stem cell research

Friend virus-induced leukemia cells of an established tissue culture line grew less well on transplantation into (BALB/c × DBA/2)F1 and (C57BL/6 × DBA/2)F1 mice than into syngeneic DBA/2 mice. In colonizing the spleens of irradiated or nonirradiated animals, 1.6 × 106 cells grafted intravenously were 2–6 times less efficient in “resistant” hybrids than in susceptible DBA/2 mice. The differential was greater when 106 cells were transplanted subcutaneously and formed solid tumors locally. Hybrid resistance to subcutaneous cell growth was stronger in male than in female mice. In segregating progeny of the backcross (BALB/c × DBA/2)F1 × DBA/2, the ratio of resistant to susceptible animals was compatible with genetic control by a single autosomal locus not associated with the marker genes T (Brachyury or Short tail), A (Agouti), and d (dilute) in linkage groups IX, V, and II, respectively. The properties of hybrid resistance to DBA/2 leukemia cells were similar to those described for nonleukemic DBA/2 bone marrow and spleen cells. Characteristic features were the relative weakness of resistance, the sex influence, and the independent assortment in backcross progeny mice of the genetic determinant of resistance and markers of linkage groups IX.