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Interleukin 2 acts directly on a Tac-positive cloned B cell line established from a patient with adult T cell leukemia.

1985; American Association of Immunologists; Volume: 135; Issue: 4 Linguagem: Inglês

10.4049/jimmunol.135.4.2474

1550-6606

Nobuyoshi Arima, Y Daitoku, Shiroh Hidaka, Hideyasu Tanaka, T Katsuki,

Animal Disease Management and Epidemiology

A Tac-positive B cell line termed K3B was established from a patient with adult T cell leukemia (ATL). This cell line had EBNA antigen and human T cell leukemic virus (HTLV) provirus besides B1 antigen and surface immunoglobulin. A cloned Tac-positive B cell line termed K3B01 was obtained from K3B by the limiting dilution method. The K3B01 cells were shown to absorb IL 2 activity in a tonsillar IL 2 preparation. By using this cloned cell line and a purified recombinant IL 2 preparation, it was shown that the proliferation of K3B01 cells was enhanced by the addition of recombinant IL 2. Moreover, this response was inhibited by anti-Tac antibody. These results demonstrate definitively that IL 2 acts directly on B cells through IL 2 receptors on them.