Peripheral chemoreceptors and cardiovascular regulation
1994; American Physiological Society; Volume: 74; Issue: 3 Linguagem: Inglês
10.1152/physrev.1994.74.3.543
ISSN1522-1210
Autores Tópico(s)Heart Rate Variability and Autonomic Control
ResumoarticlePeripheral chemoreceptors and cardiovascular regulationJ. M. MarshallJ. M. MarshallDepartment of Physiology, Medical School, University of Birmingham,United Kingdom.Published Online:01 Jul 1994https://doi.org/10.1152/physrev.1994.74.3.543MoreSectionsPDF (15 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByCarotid body chemoreceptors: physiology, pathology, and implications for health and diseaseRodrigo Iturriaga, Julio Alcayaga, Mark W. Chapleau, and Virend K. Somers2 June 2021 | Physiological Reviews, Vol. 101, No. 3The Logic of Carotid Body Connectivity to the BrainTymoteusz Zera, Davi J. A. Moraes, Melina P. da Silva, James P. Fisher, and Julian F. R. Paton5 June 2019 | Physiology, Vol. 34, No. 4Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory response in menChristoph Siebenmann, Camilla K. Ryrsø, Laura Oberholzer, James P. Fisher, Linda M. Hilsted, Peter Rasmussen, Niels H. Secher, and Carsten Lundby23 January 2019 | Journal of Applied Physiology, Vol. 126, No. 1Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice1 March 2018 | Scientific Reports, Vol. 8, No. 1Purinergic plasticity within petrosal neurons in hypertensionDavi J. A. Moraes, Melina P. da Silva, Pedro F. Spiller, Benedito H. Machado, and Julian F. R. Paton26 October 2018 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 315, No. 5Hemodynamic characteristics of postural hyperventilation: POTS with hyperventilation versus panic versus voluntary hyperventilationJulian M. Stewart, Paul Pianosi, Mohamed A. Shaban, Courtney Terilli, Maria Svistunova, Paul Visintainer, and Marvin S. Medow1 November 2018 | Journal of Applied Physiology, Vol. 125, No. 5Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure21 August 2018 | Journal of International Medical Research, Vol. 46, No. 10Insulin increases ventilation during euglycemia in humansThales C. Barbosa, Jasdeep Kaur, Seth W. Holwerda, Colin N. Young, Timothy B. Curry, John P. Thyfault, Michael J. Joyner, Jacqueline K. Limberg, and Paul J. Fadel2 July 2018 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 315, No. 1Carotid Bodies and the Integrated Cardiorespiratory Response to HypoxiaBruce G. Lindsey, Sarah C. Nuding, Lauren S. Segers, and Kendall F. Morris13 June 2018 | Physiology, Vol. 33, No. 4Guinea Pig as a Model to Study the Carotid Body Mediated Chronic Intermittent Hypoxia Effects5 June 2018 | Frontiers in Physiology, Vol. 9Hypoxia-regulated catecholamine secretion in chromaffin cells19 October 2017 | Cell and Tissue Research, Vol. 372, No. 2Physiology of static breath holding in elite apneists30 April 2018 | Experimental Physiology, Vol. 103, No. 5Carotid body: a metabolic sensor implicated in insulin resistanceSilvia V. Conde, Joana F. Sacramento, and Maria P. Guarino19 March 2018 | Physiological Genomics, Vol. 50, No. 3Sustained sympathetic activity in altitude acclimatizing lowlanders and high-altitude natives25 September 2017 | Scandinavian Journal of Medicine & Science in Sports, Vol. 28, No. 3An Improved Dynamic Model for the Respiratory Response to Exercise7 February 2018 | Frontiers in Physiology, Vol. 9Physiologic regulation of heart rate and blood pressure involves connexin 36–containing gap junctionsThe FASEB Journal, Vol. 31, No. 9Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats12 September 2017 | Physiological Reports, Vol. 5, No. 17Plasticity in breathing and arterial blood pressure following acute intermittent hypercapnic hypoxia in infant rat pups with a partial loss of 5-HT neuronsJennifer Magnusson and Kevin J. Cummings15 November 2015 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 309, No. 10Peripheral Chemoreceptor Responsiveness and Hypoxic Pulmonary Vasoconstriction in HumansHigh Altitude Medicine & Biology, Vol. 15, No. 1Hypoxic Pulmonary VasoconstrictionHigh Altitude Medicine & Biology, Vol. 14, No. 2Baroreceptor unloading in postural tachycardia syndrome augments peripheral chemoreceptor sensitivity and decreases central chemoreceptor sensitivityIndu Taneja, Marvin S. Medow, Debbie A. Clarke, Anthony J. Ocon, and Julian M. Stewart1 July 2011 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 301, No. 1Ventilatory baroreflex sensitivity in humans is not modulated by chemoreflex activationJulian M. Stewart, Eileen Rivera, Debbie A. Clarke, Ila L. Baugham, Anthony J. Ocon, Indu Taneja, Courtney Terilli, and Marvin S. Medow1 April 2011 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 300, No. 4The Effect of Altitude-Induced Hypoxia on Heart Disease: Do Acute, Intermittent, and Chronic Exposures Provide Cardioprotection?High Altitude Medicine & Biology, Vol. 12, No. 1Baroreceptor and chemoreceptor contributions to the hypertensive response to bilateral carotid occlusion in conscious miceR. M. Lataro, J. A. Castania, M. W. Chapleau, H. C. Salgado, and R. Fazan1 December 2010 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 299, No. 6Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gasesKaren C. Peebles, A. Mark Richards, Leo Celi, Ken McGrattan, Carissa J. Murrell, and Philip N. Ainslie1 October 2008 | Journal of Applied Physiology, Vol. 105, No. 4Exercise training improves peripheral chemoreflex function in heart failure rabbitsYu-Long Li, Yanfeng Ding, Chad Agnew, and Harold D. Schultz1 September 2008 | Journal of Applied Physiology, Vol. 105, No. 3The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticityPatrice G. Guyenet1 August 2008 | Journal of Applied Physiology, Vol. 105, No. 2Increased vasoconstriction predisposes to hyperpnea and postural faintIndu Taneja, Marvin S. Medow, June L. Glover, Neeraj K. Raghunath, and Julian M. Stewart1 July 2008 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 295, No. 1Cardiovascular and cerebrovascular responses to acute isocapnic and poikilocapnic hypoxia in humansCraig D. Steinback, and Marc J. Poulin1 February 2008 | Journal of Applied Physiology, Vol. 104, No. 2Effect of Altitude on the Heart and the LungsCirculation, Vol. 116, No. 19Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failureAndrea Di Vanna, Ana Maria F. W. Braga, Mateus C. Laterza, Linda M. Ueno, Maria Urbana P. B. Rondon, Antonio C. P. Barretto, Holly R. Middlekauff, and Carlos E. Negrão1 July 2007 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 293, No. 1Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respirationY. C. Tzeng, P. D. Larsen, and D. C. Galletly1 May 2007 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 292, No. 5A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexesYan-Hua Du, and Alex F. Chen1 January 2007 | Journal of Applied Physiology, Vol. 102, No. 1Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular functionAlastair J. Thomson, Gordon B. Drummond, W. Stephen Waring, David J. Webb, and Simon R. J. Maxwell1 September 2006 | Journal of Applied Physiology, Vol. 101, No. 3Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flowJulian M. Stewart, Marvin S. Medow, Neil S. Cherniack, and Benjamin H. Natelson1 August 2006 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 291, No. 2Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic functionG. D. Pinna, R. Maestri, M. T. La Rovere, E. Gobbi, and F. Fanfulla1 January 2006 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 290, No. 1Autonomic cardiovascular regulation in subjects with acute mountain sicknessPaola A. Lanfranchi, Roberto Colombo, George Cremona, Paolo Baderna, Liliana Spagnolatti, Giorgio Mazzuero, Peter Wagner, Liliana Perini, Harrieth Wagner, Carmelo Cavallaro, and Pantaleo Giannuzzi1 December 2005 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 289, No. 6Acute systemic hypoxia elevates venous but not interstitial potassium of dog skeletal muscleF. M. Mo, and H. J. Ballard1 October 2005 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 289, No. 4Effect of five nights of normobaric hypoxia on cardiovascular responses to acute isocapnic hypoxia in humans: relationship to ventilatory chemosensitivity20 February 2007 | Ergonomics, Vol. 48, No. 11-14Blutverlust, Sauerstoffatmung und prim�re HypertonieNotfall & Rettungsmedizin, Vol. 7, No. 6Regulation of gastric motility at simulated high altitude in conscious ratsMisa Yoshimoto, Mitsuko Sasaki, Nobuo Naraki, Motohiko Mohri, and Kenju Miki1 August 2004 | Journal of Applied Physiology, Vol. 97, No. 2Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expirationThomas E. Dick, Y.-H. Hsieh, Shaun Morrison, Sharon K. Coles†, and Nanduri Prabhakar1 June 2004 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 286, No. 6Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat30 March 2004 | The Journal of Physiology, Vol. 556, No. 1Different cardiorespiratory responses to hemorrhage and hyperoxia in normotensive (WKY) and spontaneously hypertensive (SHR) ratsActa Physiologica Hungarica, Vol. 91, No. 1Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide18 February 2004 | The Journal of Physiology, Vol. 555, No. 1Interactions of chemostimuli at the single cell level: studies in a model system17 December 2003 | Experimental Physiology, Vol. 89, No. 1SHORT-TERM AUTONOMIC CONTROL OF CARDIOVASCULAR FUNCTION: A MINI-REVIEW WITH THE HELP OF MATHEMATICAL MODELSJournal of Integrative Neuroscience, Vol. 02, No. 02Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise1 September 2003 | The Journal of Physiology, Vol. 551, No. 2Effect of acute exposure to 3,660 m altitude on orthostatic responses and toleranceA. P. Blaber, T. Hartley, and P. J. Pretorius1 August 2003 | Journal of Applied Physiology, Vol. 95, No. 2Renin–angiotensin system in the carotid bodyThe International Journal of Biochemistry & Cell Biology, Vol. 35, No. 6Contribution of Adenosine to the Depression of Sympathetically Evoked Vasoconstriction induced by Systemic Hypoxia in the Rat1 June 2003 | The Journal of Physiology, Vol. 549, No. 2Chronic hypoxia activates a local angiotensin-generating system in rat carotid bodyMolecular and Cellular Endocrinology, Vol. 203, No. 1-2Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia1 February 2003 | The Journal of Physiology, Vol. 546, No. 3Prenatal Nicotine Exposure Blunts the Cardiorespiratory Response to Hypoxia in LambsAmerican Journal of Respiratory and Critical Care Medicine, Vol. 166, No. 12Peripheral chemoreceptor contributions to sympathetic and cardiovascular responses during hypercapniaCanadian Journal of Physiology and Pharmacology, Vol. 80, No. 12c-Fos expression in the midbrain periaqueductal gray after chemoreceptor and baroreceptor activationLinda F. Hayward, and Marcela Von Reitzenstein1 November 2002 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 283, No. 5Roles of adenosine in skeletal muscle during systemic hypoxiaClinical and Experimental Pharmacology and Physiology, Vol. 29, No. 9Direct effect of PaCO2 on respiratory sinus arrhythmia in conscious humansNobuko Sasano, Alex E. Vesely, Junichiro Hayano, Hiroshi Sasano, Ron Somogyi, David Preiss, Kiyoyuki Miyasaka, Hirotada Katsuya, Steve Iscoe, and Joseph A. Fisher1 March 2002 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 282, No. 3Antagonism of adenosine A1 receptors in the NTS does not affect the chemoreflex in awake ratsPatrícia M. de Paula, and Benedito H. Machado1 December 2001 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 281, No. 6Effect of Intermittent Hypoxia on Cardiovascular Adaptations and Response to Progressive Hypoxia in HumansHigh Altitude Medicine & Biology, Vol. 2, No. 4A mathematical model of CO2 effect on cardiovascular regulationElisa Magosso and Mauro Ursino1 November 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 281, No. 5Exposure to hypoxia produces long-lasting sympathetic activation in humansAiliang Xie, James B. Skatrud, Dominic S. Puleo, and Barbara J. Morgan1 October 2001 | Journal of Applied Physiology, Vol. 91, No. 4The effect of systemic hypoxia on interstitial and blood adenosine, AMP, ADP and ATP in dog skeletal muscle1 October 2001 | The Journal of Physiology, Vol. 536, No. 2Ventilatory and Cardiovascular Responses to Hypoxia and Exercise in Andean Natives Living at Sea LevelHigh Altitude Medicine & Biology, Vol. 2, No. 3Acute cardiovascular response to isocapnic hypoxia. I. A mathematical modelMauro Ursino and Elisa Magosso1 July 2000 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 279, No. 1Acute cardiovascular response to isocapnic hypoxia. II. Model validationMauro Ursino, and Elisa Magosso1 July 2000 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 279, No. 1Physiological Effects of Intermittent HypoxiaHigh Altitude Medicine & Biology, Vol. 1, No. 2Cardiovascular responses to carotid chemoreceptor stimulation in the dog: their modulation by urinary bladder distension1 May 2000 | The Journal of Physiology, Vol. 524, No. 3Carotid and cardiopulmonary chemoreceptor activity increases hippocampal theta rhythm in conscious rabbitsYing-Hui Yu, and W. W. Blessing1 April 2000 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 278, No. 4Cardiovascular response to hypoxia after endurance training at altitude and sea level and after detrainingKeisho Katayama, Yasutake Sato, Yoshifumi Morotome, Norihiro Shima, Koji Ishida, Shigeo Mori, and Miharu Miyamura1 April 2000 | Journal of Applied Physiology, Vol. 88, No. 4Cardiorespiratory interactions during periodic breathing in awake chronic heart failure patientsG. D. Pinna, R. Maestri, A. Mortara, and M. T. La Rovere1 March 2000 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 278, No. 3Diuretic effect of hypoxia, hypocapnia, and hyperpnea in humans: relation to hormones and O2 chemosensitivityWulf Hildebrandt, Andy Ottenbacher, Markus Schuster, Erik R. Swenson, and Peter Bärtsch1 February 2000 | Journal of Applied Physiology, Vol. 88, No. 2Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in VertebratesEdwin W. Taylor, David Jordan, and John H. Coote1 July 1999 | Physiological Reviews, Vol. 79, No. 3Rhythmicity in Single Fiber Postganglionic Activity Supplying the Rat TailH.-J. Häbler, T. Bartsch, and W. Jänig1 May 1999 | Journal of Neurophysiology, Vol. 81, No. 5Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failureShu-Yu Sun, W. Wang, I. H. Zucker, and H. D. Schultz1 April 1999 | Journal of Applied Physiology, Vol. 86, No. 4Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake ratsAndréa S. Haibara, Leni G. H. Bonagamba, and Benedito H. Machado1 January 1999 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 276, No. 1Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A 1 receptors8 September 2004 | The Journal of Physiology, Vol. 514, No. 1Effects of Hyperventilation and Hypocapnic/Normocapnic Hypoxemia on Renal Function and Lithium Clearance in HumansAnesthesiology, Vol. 89, No. 6Differential frequency-dependent reflex integration of myelinated and nonmyelinated rat aortic baroreceptorsWei Fan, and Michael C. Andresen1 August 1998 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 275, No. 2Platelet-activating factor modulates cardiorespiratory responses in the conscious ratDavid Gozal, Gregory A. Holt, Gavin R. Graff, and José E. Torres1 August 1998 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 275, No. 2Angiotensin AT 1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity22 September 2004 | The Journal of Physiology, Vol. 510, No. 3Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigsJohannes Zanzinger, Jürgen Czachurski, and Horst Seller1 July 1998 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 275, No. 1Interactions between CO2chemoreflexes and arterial baroreflexesRebecca A. Henry, I-Li Lu, Larry A. Beightol, and Dwain L. Eckberg1 June 1998 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 274, No. 6NMDA receptors mediate peripheral chemoreceptor afferent input in the conscious ratPatricia J. Ohtake, José E. Torres, Yair M. Gozal, Gavin R. Graff, and David Gozal1 March 1998 | Journal of Applied Physiology, Vol. 84, No. 3Acetylcholine Increases Intracellular Calcium of Arterial Chemoreceptor Cells of Adult CatsMachiko Shirahata, Robert S. Fitzgerald, and James S. K. Sham1 November 1997 | Journal of Neurophysiology, Vol. 78, No. 5Hemodynamics of Chemoreflex Activation in Unanesthetized RatsHypertension, Vol. 30, No. 3The Roles of Adenosine in Regulating the Respiratory and Cardiovascular Systems in Chronically Hypoxic, Adult Rats30 September 2004 | The Journal of Physiology, Vol. 501, No. 2The effects of chronic hypoxia on renal function in the rat30 September 2004 | The Journal of Physiology, Vol. 501, No. 1 More from this issue > Volume 74Issue 3July 1994Pages 543-594 Copyright & PermissionsCopyright © 1994 the American Physiological Societyhttps://doi.org/10.1152/physrev.1994.74.3.543PubMed8036247History Published online 1 July 1994 Published in print 1 July 1994 Metrics
Referência(s)