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Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

2015; Lippincott Williams & Wilkins; Volume: 132; Issue: 6 Linguagem: Inglês

10.1161/circulationaha.114.012316

1524-4539

Indira Medina, Céline Cougoule, Maik Drechsler, Beatriz Bermúdez, Rory R. Koenen, Judith C. Sluimer, Ine M. J. Wolfs, Yvonne Döring, Veronica Hérias, Marjon Gijbels, Ilze Bot, Saskia C.A. de Jager, Christian Weber, Jack P.M. Cleutjens, Theo J.C. van Berkel, Kees-Jan Sikkink, Atilla Mócsai, Isabelle Maridonneau‐Parini, Oliver Soehnlein, Erik A.L. Biessen,

Platelet Disorders and Treatments

Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated.