Artigo Acesso aberto Revisado por pares

The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design

2007; Wiley; Volume: 8; Issue: 5 Linguagem: Inglês

10.1111/j.1399-5448.2007.00269.x

ISSN

1399-5448

Autores

Jeffrey P. Krischer, Marian Rewers, Katherine Barriga, Judith Baxter, Ann Deas, George S. Eisenbarth, Lisa M. Emery, Patricia Gesualdo, Michelle Hoffman, Jill Norris, Kathleen Waugh, Stacey Weber, Jin‐Xiong She, Andy Muir, Desmond Schatz, Diane Hopkins, Leigh Steed, Katherine Silvis, Meena N. Shankar, Yangxin Huang, Ping Yang, Wei Zheng, Hong Jie Wang, Kim Ēnglish, Richard McIndoe, Anette G. Ziegler, Ezio Bonifacio, Andrea Baumgarten, Sandra Hummel, Mathilde Kersting, Stephanie Koenig, Annette Knopff, Angelika Locher, Roswith Roth, Stefanie Schoen, Petra Schwaiger, Wolfgang Sichert‐Hellert, Christiane Winkler, Diana J. Zimmermann, Olli Simell, Kirsti Näntö‐Salonen, Jorma Ilonen, Mikael Knip, Riitta Veijola, Tuula Simell, Ulla Uusitalo, Heikki Hyöty, Suvi Virtanen, Carina Kronberg‐Kippilä, M. J. Torma, Eeva Ruohonen, Minna Romo, Elina Mäntymäki, Tiina Niininen, Mia Nyblom, Aino Stenius, Åke Lernmark, Peter Almgren, Carin Andrén-Aronsson, Eva Andersson, Sylvia Bianconi-Svensson, U.‐M. Carlsson, Corrado Cilio, Joanna Gerardsson, B. Gustavsson, Anna Hansson, Gertie Hansson, Ida Hansson, Sten A. Ivarsson, Helena Elding Larsson, E Karlsson, Anastasia Katsarou, Barbro Lernmark, Thea Massadakis, Anita Nilsson, Monica Sedig Järvirova, Birgitta Janerot-Sjöberg, Anne Wallin, Åsa Wimar, William Hagopian, Michael S. Brantley, Claire Cowen, Hui Peng, Kristen Hay, Melissa Jackson, Viktoria Stepikova, Jennifer Ugale, Jeffrey P. Krischer, Carole Bray, David Cuthbertson, Veena Gowda, Kimberly Hunt, Shu Liu, Jamie Malloy, Cristina McCarthy, Wendy McLeod, Susan Moyers, Lavanya Nallamshetty, Stephen M. Smith, Beena Akolkar, Thomas Briese, Henry Erlich, Suzanne Bennett Johnson, Steve Oberste,

Tópico(s)

Pancreatic function and diabetes

Resumo

Pediatric DiabetesVolume 8, Issue 5 p. 286-298 The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design The TEDDY Study Group, The TEDDY Study GroupSearch for more papers by this author The TEDDY Study Group, The TEDDY Study GroupSearch for more papers by this author First published: 10 September 2007 https://doi.org/10.1111/j.1399-5448.2007.00269.xCitations: 225 Jeffrey KrischerPediatrics Epidemiology CenterUniversity of South Florida3650 Spectrum BoulevardSuite 100Tampa, FL 33612USA.Tel: (813) 396-9512;fax: (813) 396-9601;e-mail: [email protected] See Appendix I. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Abstract: The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM. References 1 Green A, Patterson CC. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 2001: 44 (Suppl. 3): B3– B8. 2 Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. 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