Produção Nacional
Revisado por pares
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
2011; Springer Science+Business Media; Volume: 21; Issue: 6 Linguagem: Inglês
10.1590/s0102-695x2011005000174
ISSN1981-528X
AutoresLucimar B. Motta, Cláudia Maria Furlan, Déborah Yara Alves Cursino dos Santos, Maria Luiza Faria Salatino, Joaquim Maurício Duarte‐Almeida, Giuseppina Negri, João Ernesto de Carvalho, Ana Lúcia Tasca Góis Ruiz, Inês Cordeiro, Antônio Salatino,
Tópico(s)Insect Pest Control Strategies
ResumoCroton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.
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