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Overview of Nrf2 as Therapeutic Target in Epilepsy

2015; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 8 Linguagem: Inglês

10.3390/ijms160818348

1661-6596

Liliana Carmona‐Aparicio, Claudia Pérez-Cruz, Cecilia Zavala‐Tecuapetla, Leticia Granados-Rojas, Liliana Rivera-Espinosa, Hortencia Montesinos-Correa, Jacqueline Hernández‐Damián, José Pedraza‐Chaverrí, Aristides Iii Sampieri, Elvia Coballase-Urrutía, Noemí Cárdenas‐Rodríguez,

Tryptophan and brain disorders

Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy.