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Epidemiological studies of the non‐specific effects of vaccines: II – methodological issues in the design and analysis of cohort studies

2009; Wiley; Volume: 14; Issue: 9 Linguagem: Inglês

10.1111/j.1365-3156.2009.02302.x

1365-3156

Paddy Farrington, Martin J. Firth, Lawrence H. Moulton, Henrik Ravn, P.K. Andersen, Stephen Evans,

Influenza Virus Research Studies

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.