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On-going improvement and persistent differences in the survival for patients with colon and rectum cancer across Europe 1999–2007 – Results from the EUROCARE-5 study

2015; Elsevier BV; Volume: 51; Issue: 15 Linguagem: Inglês

10.1016/j.ejca.2015.07.024

1879-0852

Bernd Holleczek, Silvia Rossi, Domenic Agius, Kaire Innos, Pamela Minicozzi, Silvia Francisci, Monika Hackl, Nora Eisemann, Hermann Brenner, Monika Hackl, N. Zielonke, Willi Oberaigner, E. Van Eycken, K. Henau, Z. Valerianova, Nadya Dimitrova, Mario Šekerija, Miroslav Zvolský, Ladislav Dušek, Hans H. Storm, Gerda Engholm, Margit Mägi, Tiiu Aareleid, Nea Malila, Karri Seppä, Michel Velten, X. Troussard, Véronique Bouvier, Guy Launoy, Anne‐Valérie Guizard, Jean Faivre, Anne‐Marie Bouvier, P. Arveux, Marc Maynadié, Anne‐Sophie Woronoff, Michel Robaszkiewicz, Isabelle Baldi, Alain Monnereau, Brigitte Trétarre, Nadine Bossard, Aurélien Belot, Marc Colonna, F. Molinié, S. Bara, C. Schvartz, B. Lapôtre‐Ledoux, Pascale Grosclaude, M. Meyer, Roland Stabenow, Sabine Luttmann, Andrea Eberle, Hermann Brenner, Alice Nennecke, Jutta Engel, G. Schubert-Fritschle, Joachim Kieschke, Jan Heidrich, Bernd Holleczek, Alexander Katalinic, Jón G. Jónasson, Laufey Tryggvadóttír, Harry Comber, Guido Mazzoleni, A. Bulatko, Carlotta Buzzoni, Adriano Giacomin, Angela Sardo, A. Mazzei, Stefano Ferretti, Emanuele Crocetti, Gianfranco Manneschi, Gemma Gatta, Milena Sant, H. Amash, C. Amati, Paolo Baili, Franco Berrino, S. Bonfarnuzzo, Laura Botta, F. Di Salvo, Roberto Foschi, C. Margutti, E. Meneghini, Pamela Minicozzi, Annalisa Trama, Diego Serraino, Antonella Zucchetto, Roberta De Angelis, M. Caldora, Riccardo Capocaccia, E. Carrani, Silvia Francisci, Sandra Mallone, Daniela Pierannunzio, P. Roazzi, Silvia Rossi, Mariano Santaquilani, Andrea Tavilla, Fabio Pannozzo, M. Natali, L Bonelli, Marina Vercelli, Valerio Gennaro, Paolo Ricci, M. Autelitano, G. Randi, Maurizio Ponz de Leòn, C. Marchesi, Claudia Cirilli, Mario Fusco, M.F. Vitale, M. Usala, A. Traina, Maurizio Zarcone, Francesco Vitale, Rosanna Cusimano, Maria Michiara, ­Rosario ­Tumino, Paolo Giorgi Rossi, Massimo Vicentini, Fabio Falcini, Antonio Iannelli, O. Sechi, R. Cesaraccio, Silvano Piffer, A Madeddu, F. Tisano, S. Maspero, Anna Clara Fanetti, Roberto Zanetti, Stefano Rosso, P. Candela, T. Scuderi, Fabrizio Stracci, Andrea Rocca, Giovanna Tagliabue, Paolo Contiero, Angelo Paolo Dei Tos, Sandro Tognazzo, Santa Pildava, Giedrė Smailytė, Neville Calleja, R. Micallef, T.B. Johannesen, Jadwiga Rachtan, Stanisław Góźdż, Ryszard Mężyk, Jerzy Błaszczyk, Kamila Kępska, Magdalena Bielska‐Lasota, G. Forjaz de Lacerda, María José Bento, Luís Antunes, A. Miranda, A. Mayer-da-Silva, Florian Nicula, Daniela Coza, C. Safaei Diba, Maja Primic‐Žakelj, E. Almar, Antonio Navareño Mateos, M. Errezola, Nerea Larrañaga, A. Torrella-Ramos, J.M. Díaz García, A.I. Marcos-Navarro, Rafael Marcos‐Gragera, L. Vilardell, María‐José Sánchez, Esther Molina‐Montes, Carmen Navarro, María‐Dolores Chirlaque, C. Moreno-Iribas, Eva Ardanáz, Jaume Galcerán, M. Carulla, Mats Lambe, S. Khan, Seyed Mohsen Mousavi, Christine Bouchardy, M. Usel, S.M. Ess, H. Frick, Matthias Lorez, S.M. Ess, C. Herrmann, Andrea Bordoni, Alessandra Spitale, Isabelle Konzelmann, Otto Visser, V.E.P.P. Lemmens, Michel P. Coleman, Claudia Allemani, Bernard Rachet, Julia Verne, N. Easey, Gill Lawrence, Teresa Morán, Jem Rashbass, M. Roche, J. Wilkinson, Anna Gavin, Deirdre Fitzpatrick, David Brewster, Dyfed Huws, Peter D. White, R. Otter,

Colorectal Cancer Surgical Treatments

Previous population-based studies revealed major variation in survival for patients with colorectal cancer (CRC) in Europe by age and between different countries and regions, but also a sustained improvement in survival for patients with CRC in recent years. This EUROCARE-5 paper aims to update available knowledge from previous studies and to provide the latest survival estimates for CRC patients from Europe.The study analysed data of patients diagnosed with CRC from population-based cancer registries diagnosed in 29 European countries. Estimates of 1-year and 5-year relative survival (RS) were derived for patients diagnosed in 2000-2007 by European region, country and age at diagnosis. Additionally to these cohort estimates, time trends in 5-year RS were obtained for the calendar periods 1999-2001 and 2005-2007, using the period analysis methodology.European average 5-year RS for patients diagnosed with colon and rectum cancer was 57% and 56%, respectively. The analyses showed persistent differences in cancer survival across Europe with lowest survival for CRC patients observed in Eastern Europe. The analyses further showed a strong gradient in age-specific survival. Even though the study revealed sustained improvement in patient survival between 1999-2001 and 2005-2007 (absolute increase of 4 and 6 percentage points for colon and rectum, respectively), the differences in the survival for CRC patients observed at the beginning of the millennium persisted over time.Although survival for CRC patients in Europe improved markedly in the study period, significant geographic variations and a strong age gradient still persisted. Enhanced access to effective diagnostic procedures and treatment options might be the keys to reducing the existing disparities in the survival of CRC patients across Europe.