Human secretory immunoglobulin A anti-Entamoeba histolytica antibodies inhibit adherence of amebae to MDCK cells
1994; American Society for Microbiology; Volume: 62; Issue: 2 Linguagem: Inglês
10.1128/iai.62.2.764-767.1994
ISSN1098-5522
AutoresJulio César Carrero, Mario Díaz, Monica Viveros, Bertha Espinoza, E. Acosta, L Ortíz-Ortíz,
Tópico(s)Diagnosis and treatment of tuberculosis
ResumoThe presence of secretory immunoglobulin A (IgA) anti-Entamoeba histolytica antibodies in the saliva of patients with intestinal amebiasis was demonstrated by immunoblot assay, and the capacity of these antibodies to inhibit amebic adherence to a monolayer of MDCK cells was analyzed. Inhibition was due to IgA antiamebic antibodies and in part to anti-Gal-binding-lectin antibodies, as demonstrated by absorption experiments with total amebic extract and with the fraction of Gal-binding lectin. These results emphasize the relevance of secretory IgA antibodies in the phenomenon of E. histolytica adherence to epithelial cells.
Referência(s)