Hypothesis. Perchloroethylene-induced nephrotoxicity in dry-cleaning workers: is there a role for free radicals?
1998; Oxford University Press; Volume: 13; Issue: 5 Linguagem: Inglês
10.1093/ndt/13.5.1122
ISSN1460-2385
Autores Tópico(s)Carcinogens and Genotoxicity Assessment
ResumoA recent study demonstrates that dry-cleaners chronic- significant increase in a number of parameters (urinary ally exposed to perchloroethylene (PCE) show clear excretion of proteins, laminin fragments, glycosaminoevidence for renal damage [1]. PCE is a synthetic glycan, and tubular epithelial brush-border antigen) halogenated hydrocarbon. It is used extensively for indicative of PCE-induced early renal damage. The dry cleaning fabrics and for metal-degreasing opera- authors concluded that long-term monitoring is tions. PCE enters the environment when it is released required in PCE-exposed individuals for the possible to the air during handling or into the surface water development of chronic renal disease. during waste disposal. PCE has been found in at least half of the waste sites identified as hazardous by the US Environmental Protection Agency [2]. It is estim- Animal studies ated that more than 650 000 US workers may be exposed to PCE. A number of human and animal Rats exposed to 470 p.p.m. for 150 days showed studies suggest that PCE might induce a variety of increase in kidney weight and evidence for tubular cell toxic biological eVects. To prevent the toxic eVects of injury in the form of cell swelling and shedding [6 ]. PCE on workers, the US Occupational Safety and The tubular cell shedding in this animal model may be Health Administration has set limit on the amount of the severe form of what Mutti et al. [1] reported in exposure, which is 100 p.p.m. for an 8-h workday over human, i.e., ‘shedding of tubular epithelial membrane a 40-h workweek [2]. This article will review some of components’. Hayes et al. [7] examined the toxicity of the studies pertaining to the toxic eVects of PCE on PCE in the rats by administering it in their drinking the kidney and examine the evidence for a role for free water. PCE-contamination of the surface water occurs radicals in the pathogenesis of such injury. and contaminated drinking water can be a source for PCE exposure. Rats exposed to 400 and 1400 mg PCE per kg, but not 14 mg per kg, showed evidence for
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