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Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor

2015; National Academy of Sciences; Volume: 112; Issue: 46 Linguagem: Inglês

10.1073/pnas.1510745112

1091-6490

Li Zhang, Jian Yao, John Withers, Xiu‐Fang Xin, R. Banerjee, Qazi Fariduddin, Yoko Nakamura, Kinya Nomura, Gregg A. Howe, Wilhelm Boland, Honggao Yan, Sheng Yang He,

Plant and animal studies

Significance Pathogen infections can cause significant crop losses worldwide and major disturbances in natural ecosystems. Understanding the molecular basis of plant disease susceptibility is important for the development of new strategies to prevent disease outbreaks. Recent studies have identified the plant jasmonate (JA) hormone receptor as one of the common targets of pathogen virulence factors. In this study, we modified the JA receptor and showed that transgenic Arabidopsis plants with the modified JA receptor gained resistance to bacterial pathogens that secrete a potent JA-mimicking toxin to promote infection. Our results suggest that host target modification may be developed as a new strategy to protect the disease-vulnerable components of the susceptible plant against highly evolved pathogens.