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BIBTEX RIS

Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin

2015; Multidisciplinary Digital Publishing Institute; Volume: 7; Issue: 7 Linguagem: Inglês

10.3390/nu7075242

2072-6643

Roselene Oliveira, Geferson de Almeida Gonçalves, Fabíola Dorneles Inácio, Eloá Angélica Koehnlein, Cristina de Fátima de Oliveira Brum Augusto de Souza, Adelar Bracht, Rosane Marina Peralta,

Agricultural and Food Sciences

The purpose of the present work was to characterize the possible inhibition of pancreatic lipase by a tannin-rich extract obtained from the pinhão (Araucaria angustifolia seed) coat, based on the previous observation that this preparation inhibits α-amylases. Kinetic measurements of pancreatic lipase revealed that the pinhão coat tannin is an effective inhibitor. Inhibition was of the parabolic non-competitive type. The inhibition constants, \({\overline{K}}_{i1} \) and \({\overline{K}}_{i2} \), were equal to 332.7 ± 146.1 µg/mL and 321.2 \(\pm\) 93.0 µg/mL, respectively, corresponding roughly to the inhibitor concentration producing 50.