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Antibodies of IgA and IgG class in normal human urine.

1967; National Institutes of Health; Volume: 12; Issue: 6 Linguagem: Inglês

M W Turner, D. S. Rowe,

Immunodeficiency and Autoimmune Disorders

Urine collected and concentrated from three individuals after tetanus toxoid immunization has been studied for antibody activity. Gel-filtration on Sephadex G-200 was used to fractionate the urine concentrates and antibody activity in the eluates was assessed by a passive haemagglutination test. Haemagglutinating activity was demonstrated by inhibition experiments in the IgG and IgA classes of immunoglobulin but not in the IgM or IgD classes. In no case could antibody activity be ascribed to molecules smaller than intact IgG.